4-[3-hept-6-ynyl-2-(2-methoxycarbonyl-ethyl)-phenoxy]-butyric acid methyl ester

Base Information

Chemical Name:4-[3-hept-6-ynyl-2-(2-methoxycarbonyl-ethyl)-phenoxy]-butyric acid methyl ester
CAS No.:1123158-73-5
Molecular Formula:C₂₂H₃₀O₅
Molecular Weight:374.477
Hs Code.:

Synonyms:4-[3-hept-6-ynyl-2-(2-methoxycarbonyl-ethyl)-phenoxy]-butyric acid methyl ester

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Chemical Property of 4-[3-hept-6-ynyl-2-(2-methoxycarbonyl-ethyl)-phenoxy]-butyric acid methyl ester

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Technology Process of 4-[3-hept-6-ynyl-2-(2-methoxycarbonyl-ethyl)-phenoxy]-butyric acid methyl ester

There total 14 articles about 4-[3-hept-6-ynyl-2-(2-methoxycarbonyl-ethyl)-phenoxy]-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1123158-70-2
4-[2-(2-Ethoxycarbonyl-ethyl)-3-(6-oxo-hexyl)-phenoxy]-butyric acid ethyl ester

: 90965-06-3
dimethyl 1-(1-diazo-2-oxopropyl)phosphonate

: 1123158-73-5
4-[3-hept-6-ynyl-2-(2-methoxycarbonyl-ethyl)-phenoxy]-butyric acid methyl ester

Guidance literature:: With potassium carbonate; In methanol; at 20 ℃; for 5h;

Reference yield:

: 2969-81-5
Ethyl 4-bromobutyrate

: 1123158-73-5
4-[3-hept-6-ynyl-2-(2-methoxycarbonyl-ethyl)-phenoxy]-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 11 steps

1: lithium hydride / dimethyl sulfoxide / 48 h / 20 °C

2: dipotassium peroxodisulfate; copper(ll) sulfate pentahydrate / water; acetonitrile / 0.67 h / Heating / reflux

3: sodium ethanolate / ethanol / 48 h / 20 °C

4: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / chlorobenzene / 1 h / 20 - 85 °C

5: acetonitrile / 1 h / Heating / reflux; Inert atmosphere

6: ethyloxirane; acetonitrile / 15 h / Heating / reflux

7: hydrogen / palladium 10% on activated carbon / ethyl acetate / 36 h / 20 °C / 760.05 Torr

8: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 0 - 20 °C

9: carbon tetrabromide; triphenylphosphine / dichloromethane / 3 h / 0 - 10 °C

10: pyridine N-oxide; sodium hydrogencarbonate / toluene / 24 h / Heating / reflux

11: potassium carbonate / methanol / 0 - 20 °C

With pyridine N-oxide; dipotassium peroxodisulfate; N-Bromosuccinimide; copper(ll) sulfate pentahydrate; 2,2'-azobis(isobutyronitrile); carbon tetrabromide; tetrabutyl ammonium fluoride; hydrogen; sodium ethanolate; lithium hydride; sodium hydrogencarbonate; potassium carbonate; triphenylphosphine; palladium 10% on activated carbon; In tetrahydrofuran; ethyloxirane; methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; chlorobenzene; toluene; acetonitrile; 3: Horner-Wadsworth-Emmons Olefination / 5: Wittig Reaction / 6: Wittig Reaction / 11: Ohira alkynylation;

Reference yield:

: 56359-23-0
4-(2,3-dimethylphenoxy)butyric acid ethyl ester

: 1123158-73-5
4-[3-hept-6-ynyl-2-(2-methoxycarbonyl-ethyl)-phenoxy]-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: dipotassium peroxodisulfate; copper(ll) sulfate pentahydrate / water; acetonitrile / 0.67 h / Heating / reflux

2: sodium ethanolate / ethanol / 48 h / 20 °C

3: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / chlorobenzene / 1 h / 20 - 85 °C

4: acetonitrile / 1 h / Heating / reflux; Inert atmosphere

5: ethyloxirane; acetonitrile / 15 h / Heating / reflux

6: hydrogen / palladium 10% on activated carbon / ethyl acetate / 36 h / 20 °C / 760.05 Torr

7: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 0 - 20 °C

8: carbon tetrabromide; triphenylphosphine / dichloromethane / 3 h / 0 - 10 °C

9: pyridine N-oxide; sodium hydrogencarbonate / toluene / 24 h / Heating / reflux

10: potassium carbonate / methanol / 0 - 20 °C

With pyridine N-oxide; dipotassium peroxodisulfate; N-Bromosuccinimide; copper(ll) sulfate pentahydrate; 2,2'-azobis(isobutyronitrile); carbon tetrabromide; tetrabutyl ammonium fluoride; hydrogen; sodium ethanolate; sodium hydrogencarbonate; potassium carbonate; triphenylphosphine; palladium 10% on activated carbon; In tetrahydrofuran; ethyloxirane; methanol; ethanol; dichloromethane; water; ethyl acetate; chlorobenzene; toluene; acetonitrile; 2: Horner-Wadsworth-Emmons Olefination / 4: Wittig Reaction / 5: Wittig Reaction / 10: Ohira alkynylation;