(R)-2-((1R,2S)-1-Hydroxy-2-triethylsilanyloxy-propyl)-1-((R)-4-phenyl-2-thioxo-oxazolidin-3-yl)-hexan-1-one

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Chemical Name:(R)-2-((1R,2S)-1-Hydroxy-2-triethylsilanyloxy-propyl)-1-((R)-4-phenyl-2-thioxo-oxazolidin-3-yl)-hexan-1-one
CAS No.:896434-06-3
Molecular Formula:C₂₄H₃₉NO₄SSi
Molecular Weight:465.729
Hs Code.:

Synonyms:(R)-2-((1R,2S)-1-Hydroxy-2-triethylsilanyloxy-propyl)-1-((R)-4-phenyl-2-thioxo-oxazolidin-3-yl)-hexan-1-one

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Chemical Property of (R)-2-((1R,2S)-1-Hydroxy-2-triethylsilanyloxy-propyl)-1-((R)-4-phenyl-2-thioxo-oxazolidin-3-yl)-hexan-1-one

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Technology Process of (R)-2-((1R,2S)-1-Hydroxy-2-triethylsilanyloxy-propyl)-1-((R)-4-phenyl-2-thioxo-oxazolidin-3-yl)-hexan-1-one

There total 3 articles about (R)-2-((1R,2S)-1-Hydroxy-2-triethylsilanyloxy-propyl)-1-((R)-4-phenyl-2-thioxo-oxazolidin-3-yl)-hexan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 896434-05-2
1-((R)-4-Phenyl-2-thioxo-oxazolidin-3-yl)-hexan-1-one

: 109170-83-4
(S)-2-<(triethylsilyl)oxy>-2-propanal

: 896434-06-3
(R)-2-((1R,2S)-1-Hydroxy-2-triethylsilanyloxy-propyl)-1-((R)-4-phenyl-2-thioxo-oxazolidin-3-yl)-hexan-1-one

Guidance literature:: 1-((R)-4-Phenyl-2-thioxo-oxazolidin-3-yl)-hexan-1-one; With N,N,N,N,-tetramethylethylenediamine; titanium tetrachloride; In dichloromethane; at -20 ℃; for 1h;

(S)-2-<(triethylsilyl)oxy>-2-propanal; In dichloromethane; at -20 - -5 ℃; for 9h;
DOI:10.1021/jo0604890

Reference yield:

: 142-61-0
Hexanoyl chloride

: 896434-06-3
(R)-2-((1R,2S)-1-Hydroxy-2-triethylsilanyloxy-propyl)-1-((R)-4-phenyl-2-thioxo-oxazolidin-3-yl)-hexan-1-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: 100 percent / Et₃N; LiCl / tetrahydrofuran / 16.5 h / 20 °C

2.1: TiCl₄; TMEDA / CH₂Cl₂ / 1 h / -20 °C

2.2: 90 percent / CH₂Cl₂ / 9 h / -20 - -5 °C

With N,N,N,N,-tetramethylethylenediamine; titanium tetrachloride; triethylamine; lithium chloride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo0604890

Reference yield:

: 171877-37-5
(R)-4-phenyl-1,3-oxazolidine-2-thione

: 896434-06-3
(R)-2-((1R,2S)-1-Hydroxy-2-triethylsilanyloxy-propyl)-1-((R)-4-phenyl-2-thioxo-oxazolidin-3-yl)-hexan-1-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: 100 percent / Et₃N; LiCl / tetrahydrofuran / 16.5 h / 20 °C

2.1: TiCl₄; TMEDA / CH₂Cl₂ / 1 h / -20 °C

2.2: 90 percent / CH₂Cl₂ / 9 h / -20 - -5 °C

With N,N,N,N,-tetramethylethylenediamine; titanium tetrachloride; triethylamine; lithium chloride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo0604890