N-benzyl-5-(N,N-dimethylcarbamoyl)-3-formyl-4(R)-methyl-1,4-dihydropyridine

Base Information

Chemical Name:N-benzyl-5-(N,N-dimethylcarbamoyl)-3-formyl-4(R)-methyl-1,4-dihydropyridine
CAS No.:101031-30-5
Molecular Formula:C₁₇H₂₀N₂O₂
Molecular Weight:284.358
Hs Code.:

Synonyms:N-benzyl-5-(N,N-dimethylcarbamoyl)-3-formyl-4(R)-methyl-1,4-dihydropyridine

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Chemical Property of N-benzyl-5-(N,N-dimethylcarbamoyl)-3-formyl-4(R)-methyl-1,4-dihydropyridine

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Technology Process of N-benzyl-5-(N,N-dimethylcarbamoyl)-3-formyl-4(R)-methyl-1,4-dihydropyridine

There total 3 articles about N-benzyl-5-(N,N-dimethylcarbamoyl)-3-formyl-4(R)-methyl-1,4-dihydropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (R)-3-Dimethylcarbamoyl-5-((4S,5S)-4-methoxymethyl-5-phenyl-oxazolidin-2-yl)-4-methyl-4H-pyridine-1-carboxylic acid methyl ester

: 101031-30-5
N-benzyl-5-(N,N-dimethylcarbamoyl)-3-formyl-4(R)-methyl-1,4-dihydropyridine

Guidance literature:: Multi-step reaction with 2 steps

1: aq. oxalic acid

2: 51 percent / KOH / Bu₄NBr / tetrahydrofuran / 48 h / 50 °C

With potassium hydroxide; oxalic acid; tetrabutylammomium bromide; In tetrahydrofuran;
DOI:10.1021/ja00268a043

Reference yield:

: 101031-23-6
(R)-3-Dimethylcarbamoyl-5-((4S,5S)-4-methoxymethyl-5-phenyl-4,5-dihydro-oxazol-2-yl)-4-methyl-4H-pyridine-1-carboxylic acid methyl ester

: 101031-30-5
N-benzyl-5-(N,N-dimethylcarbamoyl)-3-formyl-4(R)-methyl-1,4-dihydropyridine

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) FSO₃Me; 2.) NaBH₄ / 1.) CH₂Cl₂, RT; 2.) CH₂Cl₂-THF-EtOH, 0 deg C up to RT

2: aq. oxalic acid

3: 51 percent / KOH / Bu₄NBr / tetrahydrofuran / 48 h / 50 °C

With Methyl fluorosulfonate; potassium hydroxide; sodium tetrahydroborate; oxalic acid; tetrabutylammomium bromide; In tetrahydrofuran;
DOI:10.1021/ja00268a043

Reference yield:

: 101031-20-3
2-(5-(N,N-dimethylcarbamoyl)-3-pyridyl)-4(S)-(methoxymethyl)-5(S)-phenyl-2-oxazoline

: 101031-30-5
N-benzyl-5-(N,N-dimethylcarbamoyl)-3-formyl-4(R)-methyl-1,4-dihydropyridine

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) THF, -78 deg C; 2.) THF, -78 deg C

2: 1.) FSO₃Me; 2.) NaBH₄ / 1.) CH₂Cl₂, RT; 2.) CH₂Cl₂-THF-EtOH, 0 deg C up to RT

3: aq. oxalic acid

4: 51 percent / KOH / Bu₄NBr / tetrahydrofuran / 48 h / 50 °C

With Methyl fluorosulfonate; potassium hydroxide; sodium tetrahydroborate; oxalic acid; tetrabutylammomium bromide; In tetrahydrofuran;
DOI:10.1021/ja00268a043