N-benzyl-5-(N,N-dimethylcarbamoyl)-3-(methoxymethyl)-4(R)-methyl-1,4-dihydropyridine

Base Information

Chemical Name:N-benzyl-5-(N,N-dimethylcarbamoyl)-3-(methoxymethyl)-4(R)-methyl-1,4-dihydropyridine
CAS No.:101031-36-1
Molecular Formula:C₁₈H₂₄N₂O₂
Molecular Weight:300.401
Hs Code.:

Synonyms:N-benzyl-5-(N,N-dimethylcarbamoyl)-3-(methoxymethyl)-4(R)-methyl-1,4-dihydropyridine

Suppliers and Price of N-benzyl-5-(N,N-dimethylcarbamoyl)-3-(methoxymethyl)-4(R)-methyl-1,4-dihydropyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of N-benzyl-5-(N,N-dimethylcarbamoyl)-3-(methoxymethyl)-4(R)-methyl-1,4-dihydropyridine

Chemical Property:

Purity/Quality:: 99% ，98% ^*data from raw suppliers

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Technology Process of N-benzyl-5-(N,N-dimethylcarbamoyl)-3-(methoxymethyl)-4(R)-methyl-1,4-dihydropyridine

There total 7 articles about N-benzyl-5-(N,N-dimethylcarbamoyl)-3-(methoxymethyl)-4(R)-methyl-1,4-dihydropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 101031-33-8
N-benzyl-5-(N,N-dimethylcarbamoyl)-3-(hydroxymethyl)-4(R)-methyl-1,4-dihydropyridine

: 74-88-4
methyl iodide

: 101031-36-1
N-benzyl-5-(N,N-dimethylcarbamoyl)-3-(methoxymethyl)-4(R)-methyl-1,4-dihydropyridine

Guidance literature:: With potassium hydride; In tetrahydrofuran; 1.) 0 deg C, 30 min; 2.) up to RT, 1 h;
DOI:10.1021/ja00268a043

Reference yield:

: 100-39-0
benzyl bromide

: 101031-36-1
N-benzyl-5-(N,N-dimethylcarbamoyl)-3-(methoxymethyl)-4(R)-methyl-1,4-dihydropyridine

Guidance literature:: Multi-step reaction with 3 steps

1: 51 percent / KOH / Bu₄NBr / tetrahydrofuran / 48 h / 50 °C

2: 58 percent / LiAlH₄ / tetrahydrofuran / 0 °C

3: 72 percent / KH / tetrahydrofuran / 1.) 0 deg C, 30 min; 2.) up to RT, 1 h

With potassium hydroxide; lithium aluminium tetrahydride; potassium hydride; tetrabutylammomium bromide; In tetrahydrofuran;
DOI:10.1021/ja00268a043

Reference yield:

: 101031-27-0
5-(N,N-dimethylcarbamoyl)-3-formyl-N-(methoxycarbonyl)-4(R)-methyl-1,4-dihydropyridine

: 101031-36-1
N-benzyl-5-(N,N-dimethylcarbamoyl)-3-(methoxymethyl)-4(R)-methyl-1,4-dihydropyridine

Guidance literature:: Multi-step reaction with 3 steps

1: 51 percent / KOH / Bu₄NBr / tetrahydrofuran / 48 h / 50 °C

2: 58 percent / LiAlH₄ / tetrahydrofuran / 0 °C

3: 72 percent / KH / tetrahydrofuran / 1.) 0 deg C, 30 min; 2.) up to RT, 1 h

With potassium hydroxide; lithium aluminium tetrahydride; potassium hydride; tetrabutylammomium bromide; In tetrahydrofuran;
DOI:10.1021/ja00268a043