(2S,3R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-3-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-aziridine

Base Information

Chemical Name:(2S,3R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-3-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-aziridine
CAS No.:115946-38-8
Molecular Formula:C₂₇H₄₃NO₂Si₂
Molecular Weight:469.815
Hs Code.:

Synonyms:(2S,3R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-3-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-aziridine

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Chemical Property of (2S,3R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-3-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-aziridine

Chemical Property:

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Technology Process of (2S,3R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-3-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-aziridine

There total 1 articles about (2S,3R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-3-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-aziridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 127758-12-7
(2R,3R)-(3-(2-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)ethyl)-2-oxiranyl)methan-1-ol

: 115946-38-8
(2S,3R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-3-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-aziridine

: (2R,3S)-2-Azido-1-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-diphenyl-silanyloxy)-pentan-3-ol

Guidance literature:: Yield given. Multistep reaction;
DOI:10.1016/S0040-4020(01)85849-X

Reference yield: 96.0%

: 115946-38-8
(2S,3R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-3-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-aziridine

: 98-59-9
p-toluenesulfonyl chloride

: 115946-39-9
(2S,3R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-3-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-1-(toluene-4-sulfonyl)-aziridine

Guidance literature:: In pyridine; at -20 ℃;
DOI:10.1016/S0040-4020(01)85849-X

Reference yield:

: 115946-38-8
(2S,3R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-3-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-aziridine

: 115946-44-6
(3R,4R)-4-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-3-ethyl-azetidin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: 96 percent / pyridine / -20 °C

2: 82 percent / acetic acid; H₂O / 72 h / Ambient temperature

3: CuI / diethyl ether / 1 h / -78 °C

4: 82 percent / RuCl₃(2 molpercent), NaIO₄ / CCl₄; acetonitrile; H₂O / 1 h / Ambient temperature

5: 83 percent / DCC, 4-PPY / CH₂Cl₂ / 0.25 h / Ambient temperature

6: 85 percent / Na-phthalide / 1,2-dimethoxy-ethane / 0.33 h / -78 °C

With ruthenium trichloride; sodium periodate; copper(l) iodide; 2-benzofuran-1(3H)-one; sodium; dicyclohexyl-carbodiimide; In pyridine; tetrachloromethane; 1,2-dimethoxyethane; diethyl ether; dichloromethane; water; acetic acid; acetonitrile;
DOI:10.1016/S0040-4020(01)85849-X