N-[4-[4-[4-(2-ethoxyethoxymethyl)-2-methoxyphenyl]piperazin-1-yl]butyl]benzamide

Base Information

Chemical Name:N-[4-[4-[4-(2-ethoxyethoxymethyl)-2-methoxyphenyl]piperazin-1-yl]butyl]benzamide
CAS No.:1355460-60-4
Molecular Formula:C₂₇H₃₉N₃O₄
Molecular Weight:469.624
Hs Code.:

Synonyms:N-[4-[4-[4-(2-ethoxyethoxymethyl)-2-methoxyphenyl]piperazin-1-yl]butyl]benzamide

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Chemical Property of N-[4-[4-[4-(2-ethoxyethoxymethyl)-2-methoxyphenyl]piperazin-1-yl]butyl]benzamide

Chemical Property:

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Technology Process of N-[4-[4-[4-(2-ethoxyethoxymethyl)-2-methoxyphenyl]piperazin-1-yl]butyl]benzamide

There total 5 articles about N-[4-[4-[4-(2-ethoxyethoxymethyl)-2-methoxyphenyl]piperazin-1-yl]butyl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1355460-59-1
4-[4-[4-(2-ethoxyethoxymethyl)-2-methoxyphenyl]piperazin-1-yl]butylamine

: 98-88-4
benzoyl chloride

: 1355460-60-4
N-[4-[4-[4-(2-ethoxyethoxymethyl)-2-methoxyphenyl]piperazin-1-yl]butyl]benzamide

Guidance literature:: With triethylamine; In chloroform; at 0 - 20 ℃; for 24h;
DOI:10.1016/j.bmc.2011.10.063

Reference yield:

: 1355460-56-8
1-bromo-4-(2-ethoxyethoxy)methyl-2-methoxybenzene

: 1355460-60-4
N-[4-[4-[4-(2-ethoxyethoxymethyl)-2-methoxyphenyl]piperazin-1-yl]butyl]benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; johnphos; sodium t-butanolate / toluene / 18 h / 115 °C

2: potassium carbonate; sodium iodide / acetonitrile / 24 h / Reflux

3: lithium aluminium tetrahydride / diethyl ether / 3 h / -5 - 20 °C

4: triethylamine / chloroform / 24 h / 0 - 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium aluminium tetrahydride; potassium carbonate; triethylamine; sodium iodide; johnphos; sodium t-butanolate; In diethyl ether; chloroform; toluene; acetonitrile;
DOI:10.1016/j.bmc.2011.10.063

Reference yield:

: 1355460-57-9
1-[4-(2-ethoxyethoxymethyl)-2-methoxyphenyl]piperazine

: 1355460-60-4
N-[4-[4-[4-(2-ethoxyethoxymethyl)-2-methoxyphenyl]piperazin-1-yl]butyl]benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate; sodium iodide / acetonitrile / 24 h / Reflux

2: lithium aluminium tetrahydride / diethyl ether / 3 h / -5 - 20 °C

3: triethylamine / chloroform / 24 h / 0 - 20 °C

With lithium aluminium tetrahydride; potassium carbonate; triethylamine; sodium iodide; In diethyl ether; chloroform; acetonitrile;
DOI:10.1016/j.bmc.2011.10.063