(+)-(3S,4R,7R)-5-benzyloxycarbonyl-7-(tert-butyldimethylsilyloxy)-2-(4-methoxyphenyl)-3-phenyl-2,5-diazaspiro[3.4]octan-1-one

Base Information

Chemical Name:(+)-(3S,4R,7R)-5-benzyloxycarbonyl-7-(tert-butyldimethylsilyloxy)-2-(4-methoxyphenyl)-3-phenyl-2,5-diazaspiro[3.4]octan-1-one
CAS No.:787617-86-1
Molecular Formula:C₃₃H₄₀N₂O₅Si
Molecular Weight:572.777
Hs Code.:

Synonyms:(+)-(3S,4R,7R)-5-benzyloxycarbonyl-7-(tert-butyldimethylsilyloxy)-2-(4-methoxyphenyl)-3-phenyl-2,5-diazaspiro[3.4]octan-1-one

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Chemical Property of (+)-(3S,4R,7R)-5-benzyloxycarbonyl-7-(tert-butyldimethylsilyloxy)-2-(4-methoxyphenyl)-3-phenyl-2,5-diazaspiro[3.4]octan-1-one

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Technology Process of (+)-(3S,4R,7R)-5-benzyloxycarbonyl-7-(tert-butyldimethylsilyloxy)-2-(4-methoxyphenyl)-3-phenyl-2,5-diazaspiro[3.4]octan-1-one

There total 1 articles about (+)-(3S,4R,7R)-5-benzyloxycarbonyl-7-(tert-butyldimethylsilyloxy)-2-(4-methoxyphenyl)-3-phenyl-2,5-diazaspiro[3.4]octan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 1613-90-7
4-methoxy-N-[(E)-phenylmethylidene]aniline

: (2S,4R)-1-(benzyloxycarbonyl)-4-(tert-butyldimethylsilyloxy)pyrrolidine-2-carbonyl chloride

: 787617-84-9
(-)-(3R,4S,7R)-5-benzyloxycarbonyl-7-(tert-butyldimethylsilyloxy)-2-(4-methoxyphenyl)-3-phenyl-2,5-diazaspiro[3.4]octan-1-one

: 787617-86-1
(+)-(3S,4R,7R)-5-benzyloxycarbonyl-7-(tert-butyldimethylsilyloxy)-2-(4-methoxyphenyl)-3-phenyl-2,5-diazaspiro[3.4]octan-1-one

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 16h;
DOI:10.1021/jo040163w

Reference yield:

: 787617-86-1
(+)-(3S,4R,7R)-5-benzyloxycarbonyl-7-(tert-butyldimethylsilyloxy)-2-(4-methoxyphenyl)-3-phenyl-2,5-diazaspiro[3.4]octan-1-one

: 1053247-68-9
(3S,4R,7R)-7-(tert-Butyl-dimethyl-silanyloxy)-2-(4-methoxy-phenyl)-3-phenyl-2,5-diaza-spiro[3.4]octan-1-one

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; ethyl acetate; at 20 ℃; under 760 Torr;
DOI:10.1021/jo040163w

Reference yield:

: 787617-86-1
(+)-(3S,4R,7R)-5-benzyloxycarbonyl-7-(tert-butyldimethylsilyloxy)-2-(4-methoxyphenyl)-3-phenyl-2,5-diazaspiro[3.4]octan-1-one

: (+)-(3S,4R,7R)-7-(hydroxy)-2-(4-methoxyphenyl)-3-phenyl-2,5-diazaspiro[3.4]octan-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / Pd/C / ethyl acetate; methanol / 20 °C / 760 Torr

2: 49 mg / TBAF / tetrahydrofuran / 20 °C

With tetrabutyl ammonium fluoride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; ethyl acetate;
DOI:10.1021/jo040163w