(3S,4R,7R)-7-(tert-Butyl-dimethyl-silanyloxy)-2-(4-methoxy-phenyl)-3-phenyl-2,5-diaza-spiro[3.4]octan-1-one

Base Information

Chemical Name:(3S,4R,7R)-7-(tert-Butyl-dimethyl-silanyloxy)-2-(4-methoxy-phenyl)-3-phenyl-2,5-diaza-spiro[3.4]octan-1-one
CAS No.:1053247-68-9
Molecular Formula:C₂₅H₃₄N₂O₃Si
Molecular Weight:438.642
Hs Code.:

Synonyms:(3S,4R,7R)-7-(tert-Butyl-dimethyl-silanyloxy)-2-(4-methoxy-phenyl)-3-phenyl-2,5-diaza-spiro[3.4]octan-1-one

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Chemical Property of (3S,4R,7R)-7-(tert-Butyl-dimethyl-silanyloxy)-2-(4-methoxy-phenyl)-3-phenyl-2,5-diaza-spiro[3.4]octan-1-one

Chemical Property:

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Technology Process of (3S,4R,7R)-7-(tert-Butyl-dimethyl-silanyloxy)-2-(4-methoxy-phenyl)-3-phenyl-2,5-diaza-spiro[3.4]octan-1-one

There total 3 articles about (3S,4R,7R)-7-(tert-Butyl-dimethyl-silanyloxy)-2-(4-methoxy-phenyl)-3-phenyl-2,5-diaza-spiro[3.4]octan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 787617-86-1
(+)-(3S,4R,7R)-5-benzyloxycarbonyl-7-(tert-butyldimethylsilyloxy)-2-(4-methoxyphenyl)-3-phenyl-2,5-diazaspiro[3.4]octan-1-one

: 1053247-68-9
(3S,4R,7R)-7-(tert-Butyl-dimethyl-silanyloxy)-2-(4-methoxy-phenyl)-3-phenyl-2,5-diaza-spiro[3.4]octan-1-one

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; ethyl acetate; at 20 ℃; under 760 Torr;
DOI:10.1021/jo040163w

Reference yield:

: 1613-90-7
4-methoxy-N-[(E)-phenylmethylidene]aniline

: 1053247-68-9
(3S,4R,7R)-7-(tert-Butyl-dimethyl-silanyloxy)-2-(4-methoxy-phenyl)-3-phenyl-2,5-diaza-spiro[3.4]octan-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: 35 percent / Et₃N / CH₂Cl₂ / 16 h / 20 °C

2: H₂ / Pd/C / ethyl acetate; methanol / 20 °C / 760 Torr

With hydrogen; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; ethyl acetate; 1: Staudinger reaction;
DOI:10.1021/jo040163w

Reference yield:

: (2S,4R)-1-(benzyloxycarbonyl)-4-(tert-butyldimethylsilyloxy)pyrrolidine-2-carbonyl chloride

: 1053247-68-9
(3S,4R,7R)-7-(tert-Butyl-dimethyl-silanyloxy)-2-(4-methoxy-phenyl)-3-phenyl-2,5-diaza-spiro[3.4]octan-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: 35 percent / Et₃N / CH₂Cl₂ / 16 h / 20 °C

2: H₂ / Pd/C / ethyl acetate; methanol / 20 °C / 760 Torr

With hydrogen; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; ethyl acetate; 1: Staudinger reaction;
DOI:10.1021/jo040163w