2-[5-(2-aminopyrimidin-5-yl)-1-tert-butyl-1H-benzimidazol-2-yl]benzoic acid N-acetylhydrazide

Base Information

Chemical Name:2-[5-(2-aminopyrimidin-5-yl)-1-tert-butyl-1H-benzimidazol-2-yl]benzoic acid N-acetylhydrazide
CAS No.:1310531-80-6
Molecular Formula:C₂₄H₂₅N₇O₂
Molecular Weight:443.508
Hs Code.:

Synonyms:2-[5-(2-aminopyrimidin-5-yl)-1-tert-butyl-1H-benzimidazol-2-yl]benzoic acid N-acetylhydrazide

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Chemical Property of 2-[5-(2-aminopyrimidin-5-yl)-1-tert-butyl-1H-benzimidazol-2-yl]benzoic acid N-acetylhydrazide

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Technology Process of 2-[5-(2-aminopyrimidin-5-yl)-1-tert-butyl-1H-benzimidazol-2-yl]benzoic acid N-acetylhydrazide

There total 6 articles about 2-[5-(2-aminopyrimidin-5-yl)-1-tert-butyl-1H-benzimidazol-2-yl]benzoic acid N-acetylhydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1310531-79-3
2-[5-(2-aminopyrimidin-5-yl)-1-tert-butyl-1H-benzimidazol-2-yl]benzoic acid hydrazide

: 108-24-7
acetic anhydride

: 1310531-80-6
2-[5-(2-aminopyrimidin-5-yl)-1-tert-butyl-1H-benzimidazol-2-yl]benzoic acid N-acetylhydrazide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

: 364-73-8
4-Bromo-1-fluoro-2-nitrobenzene

: 1310531-80-6
2-[5-(2-aminopyrimidin-5-yl)-1-tert-butyl-1H-benzimidazol-2-yl]benzoic acid N-acetylhydrazide

Guidance literature:: Multi-step reaction with 6 steps

1: tetrahydrofuran / 16 h / 60 °C

2: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 20 - 100 °C

3: zinc; ammonium formate / ethanol / 2 h / 50 °C

4: Oxone / N,N-dimethyl-formamide; water / 1 h / 20 °C

5: hydrazine / ethanol / 20 °C / Reflux

6: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C

With Oxone; ammonium formate; potassium carbonate; N-ethyl-N,N-diisopropylamine; hydrazine; zinc; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1135351-95-9
4-bromo-N-(tert-butyl)-2-nitroaniline

: 1310531-80-6
2-[5-(2-aminopyrimidin-5-yl)-1-tert-butyl-1H-benzimidazol-2-yl]benzoic acid N-acetylhydrazide

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 20 - 100 °C

2: zinc; ammonium formate / ethanol / 2 h / 50 °C

3: Oxone / N,N-dimethyl-formamide; water / 1 h / 20 °C

4: hydrazine / ethanol / 20 °C / Reflux

5: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C

With Oxone; ammonium formate; potassium carbonate; N-ethyl-N,N-diisopropylamine; hydrazine; zinc; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; N,N-dimethyl-formamide;