2-[5-(2-aminopyrimidin-5-yl)-1-tert-butyl-1H-benzimidazol-2-yl]benzoic acid hydrazide

Base Information

Chemical Name:2-[5-(2-aminopyrimidin-5-yl)-1-tert-butyl-1H-benzimidazol-2-yl]benzoic acid hydrazide
CAS No.:1310531-79-3
Molecular Formula:C₂₂H₂₃N₇O
Molecular Weight:401.471
Hs Code.:

Synonyms:2-[5-(2-aminopyrimidin-5-yl)-1-tert-butyl-1H-benzimidazol-2-yl]benzoic acid hydrazide

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Chemical Property of 2-[5-(2-aminopyrimidin-5-yl)-1-tert-butyl-1H-benzimidazol-2-yl]benzoic acid hydrazide

Chemical Property:

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Technology Process of 2-[5-(2-aminopyrimidin-5-yl)-1-tert-butyl-1H-benzimidazol-2-yl]benzoic acid hydrazide

There total 5 articles about 2-[5-(2-aminopyrimidin-5-yl)-1-tert-butyl-1H-benzimidazol-2-yl]benzoic acid hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1310531-78-2
2-[5-(2-amino-pyrimidin-5-yl)-1-tert-butyl-1H-benzoimidazol-2-yl]-benzoic acid methyl ester

: 1310531-79-3
2-[5-(2-aminopyrimidin-5-yl)-1-tert-butyl-1H-benzimidazol-2-yl]benzoic acid hydrazide

Guidance literature:: With hydrazine; In ethanol; at 20 ℃; Product distribution / selectivity; Reflux;

Reference yield:

: 364-73-8
4-Bromo-1-fluoro-2-nitrobenzene

: 1310531-79-3
2-[5-(2-aminopyrimidin-5-yl)-1-tert-butyl-1H-benzimidazol-2-yl]benzoic acid hydrazide

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran / 16 h / 60 °C

2: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 20 - 100 °C

3: zinc; ammonium formate / ethanol / 2 h / 50 °C

4: Oxone / N,N-dimethyl-formamide; water / 1 h / 20 °C

5: hydrazine / ethanol / 20 °C / Reflux

With Oxone; ammonium formate; potassium carbonate; hydrazine; zinc; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1135351-95-9
4-bromo-N-(tert-butyl)-2-nitroaniline

: 1310531-79-3
2-[5-(2-aminopyrimidin-5-yl)-1-tert-butyl-1H-benzimidazol-2-yl]benzoic acid hydrazide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 20 - 100 °C

2: zinc; ammonium formate / ethanol / 2 h / 50 °C

3: Oxone / N,N-dimethyl-formamide; water / 1 h / 20 °C

4: hydrazine / ethanol / 20 °C / Reflux

With Oxone; ammonium formate; potassium carbonate; hydrazine; zinc; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; N,N-dimethyl-formamide;