4-[1-(2-aminopyrimidin-4-yl)-3-methylindazol-6-yl]-2-[1-(triphenylmethyl)imidazol-4-yl]but-3-yn-2-ol

Base Information

Chemical Name:4-[1-(2-aminopyrimidin-4-yl)-3-methylindazol-6-yl]-2-[1-(triphenylmethyl)imidazol-4-yl]but-3-yn-2-ol
CAS No.:1394120-03-6
Molecular Formula:C₃₈H₃₁N₇O
Molecular Weight:601.71
Hs Code.:

Synonyms:4-[1-(2-aminopyrimidin-4-yl)-3-methylindazol-6-yl]-2-[1-(triphenylmethyl)imidazol-4-yl]but-3-yn-2-ol

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Chemical Property of 4-[1-(2-aminopyrimidin-4-yl)-3-methylindazol-6-yl]-2-[1-(triphenylmethyl)imidazol-4-yl]but-3-yn-2-ol

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Technology Process of 4-[1-(2-aminopyrimidin-4-yl)-3-methylindazol-6-yl]-2-[1-(triphenylmethyl)imidazol-4-yl]but-3-yn-2-ol

There total 4 articles about 4-[1-(2-aminopyrimidin-4-yl)-3-methylindazol-6-yl]-2-[1-(triphenylmethyl)imidazol-4-yl]but-3-yn-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 61985-25-9
1-(1H-imidazol-4-yl)ethan-1-one

: 1394120-03-6
4-[1-(2-aminopyrimidin-4-yl)-3-methylindazol-6-yl]-2-[1-(triphenylmethyl)imidazol-4-yl]but-3-yn-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / N,N-dimethyl-formamide / 2 h / 20 °C

2: lithium diisopropyl amide / tetrahydrofuran / 1.42 h / -78 - 20 °C / Inert atmosphere

With triethylamine; lithium diisopropyl amide; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 7746-27-2
6-bromo-3-methyl-1 H-indazole

: 1394120-03-6
4-[1-(2-aminopyrimidin-4-yl)-3-methylindazol-6-yl]-2-[1-(triphenylmethyl)imidazol-4-yl]but-3-yn-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydride / N,N-dimethyl-formamide / 2.17 h / 0 - 60 °C

2: piperidine / copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1.5 h / 65 °C / Inert atmosphere

3: tetrabutyl ammonium fluoride / tetrahydrofuran; methanol; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran / 0.5 h

4: lithium diisopropyl amide / tetrahydrofuran / 1.42 h / -78 - 20 °C / Inert atmosphere

With piperidine; tetrabutyl ammonium fluoride; sodium hydride; lithium diisopropyl amide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; N,N-dimethyl-formamide;

Reference yield:

: 1394119-37-9
4-(6-bromo-3-methyl-1H-indazol-1-yl)pyrimidin-2-amine

: 1394120-03-6
4-[1-(2-aminopyrimidin-4-yl)-3-methylindazol-6-yl]-2-[1-(triphenylmethyl)imidazol-4-yl]but-3-yn-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1: piperidine / copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1.5 h / 65 °C / Inert atmosphere

2: tetrabutyl ammonium fluoride / tetrahydrofuran; methanol; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran / 0.5 h

3: lithium diisopropyl amide / tetrahydrofuran / 1.42 h / -78 - 20 °C / Inert atmosphere

With piperidine; tetrabutyl ammonium fluoride; lithium diisopropyl amide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran;