6-Bromo-3-methyl indazole

Base Information

• Chemical Name: 6-Bromo-3-methyl indazole
• CAS No.: 7746-27-2
• Molecular Formula: C8H7BrN2
• Molecular Weight: 211.061
• Hs Code.: 2933998090
• Mol file: 7746-27-2.mol

Synonyms:6-BROMO-3-METHYL INDAZOLE;1H-Indazole, 6-broMo-3-Methyl-

Chemical Property of 6-Bromo-3-methyl indazole

Chemical Property:

• Melting Point: 191-192℃
• Boiling Point: 341.417 °C at 760 mmHg
• PKA: 13.17±0.40(Predicted)
• Flash Point: 160.284 °C
• PSA: 28.68000
• Density: 1.655 g/cm³
• LogP: 2.63380
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

6-Bromo-3-methylindazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Bromo-3-methyl indazole

There total 7 articles about 6-Bromo-3-methyl indazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

1-(4-bromo-2-fluorophenyl)ethanone hydrazone (947685-09-8) → 6-bromo-3-methyl-1 H-indazole (7746-27-2)

Guidance literature:

In ethylene glycol; at 165 ℃; for 6h;

Reference yield: 72.0%

4-bromo-2-fluoroacetophenone (625446-22-2) → 6-bromo-3-methyl-1 H-indazole (7746-27-2)

Guidance literature:

With hydrazine hydrate; In ethylene glycol; at 165 ℃; for 12h;

Reference yield:

4-bromo-2-fluorobenzaldehyde (57848-46-1) → 6-bromo-3-methyl-1 H-indazole (7746-27-2)

Guidance literature:

Multi-step reaction with 3 steps

1: diethyl ether / 12 h / 20 °C / Cooling with ice

2: dipyridinium dichromate / N,N-dimethyl-formamide / 12 h / 20 °C

3: hydrazine hydrate / ethylene glycol / 12 h / 165 °C

With dipyridinium dichromate; hydrazine hydrate; In diethyl ether; ethylene glycol; N,N-dimethyl-formamide;

upstream raw materials:

1-(4-bromo-2-fluorophenyl)ethanone hydrazone

4-bromo-2-fluoroacetophenone

4-bromo-2-fluorobenzaldehyde

1-(4-bromo-2-fluorophenyl)ethanol

Downstream raw materials:

6-bromo-1,3-dimethyl-1H-indazole

6-bromo-2,3-dimethyl-1H-indazole

2-((4-amino-3-(3-methyl-1H-indazol-6-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-3-phenyl-4H-chromen-4-one

2-((4-amino-3-(3-methyl-1H-indazol-6-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-3-(3-fluorophenyl)-4H-chromen-4-one

Refernces

• 1、 -. "HEPARAN SULFATE BIOSYNTHESIS INHIBITORS FOR THE TREATMENT OF DISEASES". Paragraph 000673. . Retrieved 2016/05/02.
• 2、 -. "PHTALAZINE DERIVATIVES AS JAK1 INHIBITORS". Page/Page column 71; 72. . Retrieved 2012/04/04.