URACIL-6-D1

Base Information

• Chemical Name: URACIL-6-D1
• CAS No.: 24897-51-6
• Molecular Formula: C₄H₄N₂O₂
• Molecular Weight: 113.08
• Mol file: 24897-51-6.mol

Synonyms:Uracil-6-d(7CI,8CI);

Chemical Property of URACIL-6-D1

Chemical Property:

• Melting Point: 320-322 °C (decomp)
• PSA: 65.72000
• Density: 1.333 g/cm³
• LogP: -0.93680

Purity/Quality:

99% ^*data from raw suppliers

Uracil-6-d1 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Uracil-6-d1 is used in preparation of stabilized nucleotides for medical treatment of hepatitis C, RSV, HSV and as antitumor agents.

Technology Process of URACIL-6-D1

There total 3 articles about URACIL-6-D1 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

<3-2H>propiolic acid (18910-53-7) + urea (57-13-6) → uracil-6-d (24897-51-6)

Guidance literature:

With PPA; at 90 ℃; for 4.5h;

DOI:10.1021/ja00125a004

Reference yield:

1,3,4-D3-Uracil (24897-54-9) → uracil-6-d (24897-51-6)

Guidance literature:

With water;

DOI:10.1016/0584-8539(84)80073-2

Reference yield:

→ uracil-6-d (24897-51-6)

Guidance literature:

5-Brom-uracil-6-d, H2/Pd/BaSO4/MgO in wss.A./CaCO3;

upstream raw materials:

1,3,4-D₃-Uracil

<3-2H>propiolic acid

urea

Downstream raw materials:

1,3,5,6-tetradeuterio-1H-pyrimidine-2,4-dione

Refernces

• 1、 Barnes, A. J.,Stuckey, M. A.,Gall, L. Le. "Nucleic acid bases studed by matrix isolation vibrational spectroscopy: uracil and deuterated uracils". . p. 419 - 432. Retrieved 2007/10/02.