7-exo-<(benzyloxy)methyl>-α-1-(fluorodimethylsilyl)-β-2,α-4-diacetoxy-α-3,7-dimethylbicyclo<4.1.0>heptane

Base Information

Chemical Name:7-exo-<(benzyloxy)methyl>-α-1-(fluorodimethylsilyl)-β-2,α-4-diacetoxy-α-3,7-dimethylbicyclo<4.1.0>heptane
CAS No.:143143-79-7
Molecular Formula:C₂₃H₃₃FO₅Si
Molecular Weight:436.596
Hs Code.:

Synonyms:7-exo-<(benzyloxy)methyl>-α-1-(fluorodimethylsilyl)-β-2,α-4-diacetoxy-α-3,7-dimethylbicyclo<4.1.0>heptane

Suppliers and Price of 7-exo-<(benzyloxy)methyl>-α-1-(fluorodimethylsilyl)-β-2,α-4-diacetoxy-α-3,7-dimethylbicyclo<4.1.0>heptane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 7-exo-<(benzyloxy)methyl>-α-1-(fluorodimethylsilyl)-β-2,α-4-diacetoxy-α-3,7-dimethylbicyclo<4.1.0>heptane

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 7-exo-<(benzyloxy)methyl>-α-1-(fluorodimethylsilyl)-β-2,α-4-diacetoxy-α-3,7-dimethylbicyclo<4.1.0>heptane

There total 8 articles about 7-exo-<(benzyloxy)methyl>-α-1-(fluorodimethylsilyl)-β-2,α-4-diacetoxy-α-3,7-dimethylbicyclo<4.1.0>heptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 139177-19-8,143234-68-8
7-exo-<(benzyloxy)methyl>-α-1-(allyldimethylsilyl)-β-2,α-4-diacetoxy-α-3,7-dimethylbicyclo<4.1.0>heptane

: 143143-79-7
7-exo-<(benzyloxy)methyl>-α-1-(fluorodimethylsilyl)-β-2,α-4-diacetoxy-α-3,7-dimethylbicyclo<4.1.0>heptane

Guidance literature:: With bromine; pyridine hydrogenfluoride; In dichloromethane; for 2h; Ambient temperature;
DOI:10.1021/jo00046a017

Reference yield:

: 100-39-0
benzyl bromide

: 143143-79-7
7-exo-<(benzyloxy)methyl>-α-1-(fluorodimethylsilyl)-β-2,α-4-diacetoxy-α-3,7-dimethylbicyclo<4.1.0>heptane

Guidance literature:: Multi-step reaction with 5 steps

1: 42.2 percent / NaH, n-Bu₄NI / tetrahydrofuran / 3 h

2: 1.) LDA, HMPA / 1.) THF, r. t., 14 h

3: 55 percent / AlCl₃, LiAlH₄ / diethyl ether; tetrahydrofuran / 6 h / Ambient temperature

4: 95 percent / Et₃N, DMAP / CH₂Cl₂ / 21 h / Ambient temperature

5: 79 percent / HF*Py, Br₂ / CH₂Cl₂ / 2 h / Ambient temperature

With N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; lithium aluminium tetrahydride; aluminium trichloride; bromine; tetra-(n-butyl)ammonium iodide; sodium hydride; pyridine hydrogenfluoride; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/jo00046a017

Reference yield:

: 39903-97-4
(S)-carvone oxide

: 143143-79-7
7-exo-<(benzyloxy)methyl>-α-1-(fluorodimethylsilyl)-β-2,α-4-diacetoxy-α-3,7-dimethylbicyclo<4.1.0>heptane

Guidance literature:: Multi-step reaction with 7 steps

1: 81 percent / m-CPBA / CH₂Cl₂ / 6 h

2: t-BuOK / 2-methyl-propan-2-ol / 5 h / 20 °C / <20 deg C

3: 42.2 percent / NaH, n-Bu₄NI / tetrahydrofuran / 3 h

4: 1.) LDA, HMPA / 1.) THF, r. t., 14 h

5: 55 percent / AlCl₃, LiAlH₄ / diethyl ether; tetrahydrofuran / 6 h / Ambient temperature

6: 95 percent / Et₃N, DMAP / CH₂Cl₂ / 21 h / Ambient temperature

7: 79 percent / HF*Py, Br₂ / CH₂Cl₂ / 2 h / Ambient temperature

With N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; lithium aluminium tetrahydride; aluminium trichloride; potassium tert-butylate; bromine; tetra-(n-butyl)ammonium iodide; sodium hydride; pyridine hydrogenfluoride; triethylamine; 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; dichloromethane; tert-butyl alcohol;
DOI:10.1021/jo00046a017