Trifluoro-methanesulfonic acid 3-(2-benzyloxy-ethoxy)-9,10-dihydro-8-aza-benzo[g]chrysen-12-yl ester

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Chemical Name:Trifluoro-methanesulfonic acid 3-(2-benzyloxy-ethoxy)-9,10-dihydro-8-aza-benzo[g]chrysen-12-yl ester
CAS No.:186970-85-4
Molecular Formula:C₃₁H₂₄F₃NO₅S
Molecular Weight:579.596
Hs Code.:

Synonyms:Trifluoro-methanesulfonic acid 3-(2-benzyloxy-ethoxy)-9,10-dihydro-8-aza-benzo[g]chrysen-12-yl ester

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Chemical Property of Trifluoro-methanesulfonic acid 3-(2-benzyloxy-ethoxy)-9,10-dihydro-8-aza-benzo[g]chrysen-12-yl ester

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Technology Process of Trifluoro-methanesulfonic acid 3-(2-benzyloxy-ethoxy)-9,10-dihydro-8-aza-benzo[g]chrysen-12-yl ester

There total 7 articles about Trifluoro-methanesulfonic acid 3-(2-benzyloxy-ethoxy)-9,10-dihydro-8-aza-benzo[g]chrysen-12-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 186970-61-6
Trifluoro-methanesulfonic acid 5-[4-(2-benzyloxy-ethoxy)-phenyl]-6-pyridin-2-yl-7,8-dihydro-naphthalen-2-yl ester

: 186970-85-4
Trifluoro-methanesulfonic acid 3-(2-benzyloxy-ethoxy)-9,10-dihydro-8-aza-benzo[g]chrysen-12-yl ester

Guidance literature:: In cyclohexane; for 2h; Irradiation;
DOI:10.1021/jo9618029

Reference yield:

: 622-08-2,1201808-31-2
2-Benzyloxyethanol

: 186970-85-4
Trifluoro-methanesulfonic acid 3-(2-benzyloxy-ethoxy)-9,10-dihydro-8-aza-benzo[g]chrysen-12-yl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 98 percent / Et₃N / tetrahydrofuran / 0.5 h / Ambient temperature

2: 87 percent / K₂CO₃ / butan-2-one / 72 h / 80 °C

3: 1.) lithium diisopropylamide, 3.) aq. HCl / 1) THF, hexane, -78 deg C --> rt, 1 h; 2) THF, hexane, rt, 3 h; 3) 10 min

4: 1.) NaH / 1) DMF, rt, 4 h; 2) DMF, rt, 48 h

5: 75 percent / methanesulfonic acid / CH₂Cl₂ / 24 h / Ambient temperature

6: 87 percent / 2,6-lutidine / CH₂Cl₂ / 1 h / 0 - 20 °C

7: 65 percent / cyclohexane / 2 h / Irradiation

With 2,6-dimethylpyridine; hydrogenchloride; methanesulfonic acid; sodium hydride; potassium carbonate; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; cyclohexane; butanone;
DOI:10.1021/jo9618029

Reference yield:

: 58841-52-4
2-(benzyloxy)ethyl methanesulfonate

: 186970-85-4
Trifluoro-methanesulfonic acid 3-(2-benzyloxy-ethoxy)-9,10-dihydro-8-aza-benzo[g]chrysen-12-yl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 87 percent / K₂CO₃ / butan-2-one / 72 h / 80 °C

2: 1.) lithium diisopropylamide, 3.) aq. HCl / 1) THF, hexane, -78 deg C --> rt, 1 h; 2) THF, hexane, rt, 3 h; 3) 10 min

3: 1.) NaH / 1) DMF, rt, 4 h; 2) DMF, rt, 48 h

4: 75 percent / methanesulfonic acid / CH₂Cl₂ / 24 h / Ambient temperature

5: 87 percent / 2,6-lutidine / CH₂Cl₂ / 1 h / 0 - 20 °C

6: 65 percent / cyclohexane / 2 h / Irradiation

With 2,6-dimethylpyridine; hydrogenchloride; methanesulfonic acid; sodium hydride; potassium carbonate; lithium diisopropyl amide; In dichloromethane; cyclohexane; butanone;
DOI:10.1021/jo9618029