58841-52-4

Basic information

• Product Name: 2-(benzyloxy)ethyl methanesulfonate
• Synonyms: 2-(Benzyloxy)ethyl methanesulfonate; ethanol, 2-(phenylmethoxy)-, methanesulfonate
• CAS NO: 58841-52-4
• Molecular Formula: C₁₀H₁₄O₄S
• Molecular Weight: 230.2808
• Mol File: 58841-52-4.mol
• Article Data: 27

Chemical Properties

• Boiling Point: 375.438°C at 760 mmHg
• Flash Point: 180.858°C
• Density: 1.218g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.521
• CAS DataBase Reference: 2-(benzyloxy)ethyl methanesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(benzyloxy)ethyl methanesulfonate(58841-52-4)
• EPA Substance Registry System: 2-(benzyloxy)ethyl methanesulfonate(58841-52-4)

Safety Data

• Hazardous Substances Data: 58841-52-4(Hazardous Substances Data)

Usage

General Description

2-(benzyloxy)ethyl methanesulfonate is a chemical compound with the molecular formula C10H12O3S. It is an organic compound that is commonly used as a reagent in organic synthesis. 2-(benzyloxy)ethyl methanesulfonate is derived from methanesulfonic acid and has a benzyl group attached to the ethyl group. It is often used as a protective group for alcohols and a precursor for the synthesis of various pharmaceuticals and other organic molecules. Additionally, it is an important intermediate in the synthesis of various organic compounds, making it a valuable reagent in the field of organic chemistry.

Upstream product

• 100-44-7 benzyl chloride 
• 622-08-2 2-Benzyloxyethanol 
• 100-39-0 benzyl bromide 
• 144-55-8 sodium hydrogencarbonate 
• 124-63-0 methanesulfonyl chloride 
• 121653-72-3 (2-Benzyloxy-ethoxy)-hydroxy-acetic acid methyl ester 

Downstream Products

• 854714-90-2 2-(2-benzyloxy-ethyl)-2-phenyl-cyclohexanone 
• 66021-75-8 ((2-azidoethoxy)methyl)benzene 
• 169548-30-5 α-{2-[1-(α,α,α-trifluoro-4-tolyl)-2-imidazolidinon-3-yl]ethoxy}toluene 
• 162748-21-2 1-(4-trifluoromethylphenyl)-2-imidazolidinone 
• 186970-32-1 4-(2-benzyloxyethoxy)benzaldehyde 
• 1462-37-9 bromoethyl-2-benzyl ether 
• 909569-44-4 2-(2-(benzyloxy)ethyl)-3-oxobutyric acid methyl ester 

Relevant articles and documents

Discovery and mechanism of action studies of 4,6-diphenylpyrimidine-2-carbohydrazides as utrophin modulators for the treatment of Duchenne muscular dystrophy

Duchenne muscular dystrophy is a fatal disease with no cure, caused by lack of the cytoskeletal protein dystrophin. Upregulation of utrophin, a dystrophin paralogue, offers a potential therapy independent of mutation type. The failure of first-in-class utrophin modulator ezutromid/SMT C1100 in Phase II clinical trials necessitates development of compounds with better efficacy, physicochemical and ADME properties and/or complementary mechanisms. We have discovered and performed a preliminary optimisation of a novel class of utrophin modulators using an improved phenotypic screen, where reporter expression is derived from the full genomic context of the utrophin promoter. We further demonstrate through target deconvolution studies, including expression analysis and chemical proteomics, that this compound series operates via a novel mechanism of action, distinct from that of ezutromid.

6-HETEROARYLOXY BENZIMIDAZOLES AND AZABENZIMIDAZOLES AS JAK2 INHIBITORS

The present disclosure provides 6-heteroaryloxy benzimidazole and azabenzimidazole compounds and compositions thereof useful for inhibiting JAK2.

Antibody drug conjugate, intermediate, preparation method, pharmaceutical composition and uses thereof

Disclosed are an antibody drug conjugate IB, which uses ether linkages for connection, and improves the water solubility, stability and cytotoxicity in vivo and in intro, and an intermediate, a pharmaceutical composition, and uses of the antibody drug conjugate. The antibody drug conjugate has simple synthetic steps and a high yield.