PROPIONIC-2,2-D2 ACID

Base Information

• Chemical Name: PROPIONIC-2,2-D2 ACID
• CAS No.: 19136-91-5
• Molecular Formula: C3H4D2O2
• Molecular Weight: 76.0636
• Mol file: 19136-91-5.mol

Synonyms:Propionic-2,2-d2acid (7CI,8CI);a-Dideuteropropanolicacid;

Chemical Property of PROPIONIC-2,2-D2 ACID

Chemical Property:

• Vapor Pressure: 4.23mmHg at 25°C
• Melting Point: -24 - -23 °C(lit.)
• Refractive Index: 1.397
• Boiling Point: 141.7 °C at 760 mmHg
• Flash Point: 57.7 °C
• PSA: 37.30000
• Density: 1.046 g/cm³
• LogP: 0.48100

Purity/Quality:

98%,99%, ^*data from raw suppliers

Propionic-d2Acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34
• Safety Statements: 23-36-45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of PROPIONIC-2,2-D2 ACID

There total 4 articles about PROPIONIC-2,2-D2 ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

p-nitrophenyl propanoate-α-d2 → 4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) + (2,2-d2)-propionic acid (19136-91-5)

Guidance literature:

With alkaline solution; In water; acetonitrile; at 24.9 - 25.1 ℃; Rate constant; carbonate buffer pH 10.70;

DOI:10.1021/ja00250a026

Reference yield:

Diethyl methylmalonate (609-08-5) → (2,2-d2)-propionic acid (19136-91-5)

Guidance literature:

With ethanol; water-d2; sodium; phosphorus trichloride; Multistep reaction;

Reference yield:

1,1-dideuterio-1-bromoethane (3652-84-4) + carbon dioxide (124-38-9,18923-20-1) → (2,2-d2)-propionic acid (19136-91-5)

Guidance literature:

With magnesium;

DOI:10.1021/j100265a011

upstream raw materials:

1,1-dideuterio-1-bromoethane

carbon dioxide

Diethyl methylmalonate

Downstream raw materials:

2,2,3,3-²H-butane

methyl valerate

dimethyl sebacate

methyl hexanoate

Refernces

• 1、 Matta, Michael S.,Broadway, Dale E.,Stroot, Michele K.. "Parallel Behavior in Kinetic and NMR Effects: Secondary Deuterium Isotope Effects on the Alkaline Hydrolysis of Esters". . p. 4916 - 4918. Retrieved 2007/10/02.
• 2、 Boden, Neville,Bushby, Richard J.,Clark, Leslie D.. "The Synthesis of Specifically and Selectively Deuteriated 4,4'-Bisalkoxyazoxybenzene Derivatives". . p. 543 - 551. Retrieved 2007/10/02.