N-[4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-2-methoxyphenyl]-N'-[2-(propane-2-sulfonyl)phenyl]-1,3,5-triazine-2,4-diamine

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Chemical Name:N-[4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-2-methoxyphenyl]-N'-[2-(propane-2-sulfonyl)phenyl]-1,3,5-triazine-2,4-diamine
CAS No.:1097917-81-1
Molecular Formula:C₂₆H₃₂N₆O₅S
Molecular Weight:540.643
Hs Code.:

Synonyms:N-[4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-2-methoxyphenyl]-N'-[2-(propane-2-sulfonyl)phenyl]-1,3,5-triazine-2,4-diamine

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Chemical Property of N-[4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-2-methoxyphenyl]-N'-[2-(propane-2-sulfonyl)phenyl]-1,3,5-triazine-2,4-diamine

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Technology Process of N-[4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-2-methoxyphenyl]-N'-[2-(propane-2-sulfonyl)phenyl]-1,3,5-triazine-2,4-diamine

There total 5 articles about N-[4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-2-methoxyphenyl]-N'-[2-(propane-2-sulfonyl)phenyl]-1,3,5-triazine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1061358-47-1
4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-2-methoxyaniline

: 1097920-74-5
4-chloro-N-[2-(propane-2-sulfonyl)phenyl]-1,3,5-triazin-2-amine

: 1097917-81-1
N-[4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-2-methoxyphenyl]-N'-[2-(propane-2-sulfonyl)phenyl]-1,3,5-triazine-2,4-diamine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 120 ℃; for 0.666667h; Microwave irradiation;
DOI:10.1248/cpb.c17-00784

Reference yield:

: 76697-50-2
1-amino-2-(isopropylsulphonyl)benzene

: 1097917-81-1
N-[4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-2-methoxyphenyl]-N'-[2-(propane-2-sulfonyl)phenyl]-1,3,5-triazine-2,4-diamine

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 72 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 0.67 h / 120 °C / Microwave irradiation

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one;
DOI:10.1248/cpb.c17-00784

Reference yield:

: 177-11-7
4,4-ethylenedioxy-piperidine

: 1097917-81-1
N-[4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-2-methoxyphenyl]-N'-[2-(propane-2-sulfonyl)phenyl]-1,3,5-triazine-2,4-diamine

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 70 °C

2: hydrogen; palladium 10% on activated carbon / ethanol; tetrahydrofuran / 8 h / 20 °C / 760.05 Torr

3: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 0.67 h / 120 °C / Microwave irradiation

With palladium 10% on activated carbon; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; ethanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.c17-00784