(R,S)-Nornicotine-d4

Base Information

Chemical Name:(R,S)-Nornicotine-d4
CAS No.:66148-18-3
Molecular Formula:C₉H₁₂N₂
Molecular Weight:152.176
Hs Code.:
European Community (EC) Number:804-112-8
DSSTox Substance ID:DTXSID30478556
Mol file:66148-18-3.mol

Synonyms:66148-18-3;(R,S)-Nornicotine-d4;(+/-)-Nornicotine-d4;2,3,4,6-tetradeuterio-5-pyrrolidin-2-ylpyridine;(R,S)-Nornicotine-d4 (100 ug/mL in Methanol);(+/-)-Nornicotine-2,4,5,6-d4 (pyridine-d4);Nornicotine-d4;3-(Pyrrolidin-2-yl)(~2~H_4_)pyridine;DTXSID30478556;3-(pyrrolidin-2-yl)(?H?)pyridine;AKOS030242628;1ST14014D4;()-Nornicotine-2,4,5,6-d4 (pyridine-d4);D97912;A935325

Suppliers and Price of (R,S)-Nornicotine-d4

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(R,S)-Nornicotine-d4
50mg
$ 435.00

TRC
(R,S)-Nornicotine-d4
25mg
$ 300.00

Sigma-Aldrich
(±)-Nornicotine-d4 100?μg/mLinmethanol,ampuleof1?mL,certifiedreferencematerial,Cerilliant?
1 mL
$ 112.00

Sigma-Aldrich
(±)-Nornicotine-d4 100 μg/mL in methanol, ampule of 1 mL, certified reference material
072-1ml
$ 109.00

American Custom Chemicals Corporation
NORNICOTINE-D4 95.00%
50MG
$ 2310.00

American Custom Chemicals Corporation
NORNICOTINE-D4 95.00%
10MG
$ 1732.50

American Custom Chemicals Corporation
NORNICOTINE-D4 95.00%
5MG
$ 831.88

American Custom Chemicals Corporation
NORNICOTINE-D4 95.00%
1MG
$ 721.88

American Custom Chemicals Corporation
(RS)-NORNICOTINE-D4 95.00%
5MG
$ 499.62

Total 17 raw suppliers

Chemical Property of (R,S)-Nornicotine-d4

Chemical Property:

Appearance/Colour:colourless oil
Vapor Pressure:0.007mmHg at 25°C
Refractive Index:1.536
Boiling Point:269.999 °C at 760 mmHg
Flash Point:111.291 °C
PSA：24.92000
Density:1.071 g/cm³
LogP:1.83490
Storage Temp.:-20°C Freezer, Under Inert Atmosphere
XLogP3:0.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:152.125155375
Heavy Atom Count:11
Complexity:125

Purity/Quality:

98%,99%, ^*data from raw suppliers

(R,S)-Nornicotine-d4 ^*data from reagent suppliers

Safty Information:

Pictogram(s): F,T
Hazard Codes:F,T
Statements: 11-23/24/25-39/23/24/25
Safety Statements: 7-16-36/37-45

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC(NC1)C2=CN=CC=C2
Isomeric SMILES:[2H]C1=C(C(=C(N=C1[2H])[2H])C2CCCN2)[2H]
Uses Labelled (RS)-Nornicotine (N757000). (RS)-Nornicotine is a tobacco alkaloid and the major Nicotine (N412420) metabolite in brain. Nornicotine appears to activate different nAChR subtypes, has a better pharmacokinetic profile, and produces less toxicity than Nicotine. Nornicotine shows a significant analgesic activity.

Technology Process of (R,S)-Nornicotine-d4

There total 3 articles about (R,S)-Nornicotine-d4 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 66148-17-2
2,4,5,6-tetradeuterio-myosmine

: 66148-18-3
2,4,5,6-tetradeuterio-nornicotine

Guidance literature:: With sodium tetrahydroborate; In methanol; acetic acid; at 20 - 50 ℃; for 3h;
DOI:10.1002/jlcr.1508

Reference yield:

: 764661-25-8
3-(2,4,5,6-tetradeuterio-nicotinoyl)pyrrolidin-2-one

: 66148-18-3
2,4,5,6-tetradeuterio-nornicotine

Guidance literature:: Multi-step reaction with 2 steps

1: 68 percent / aq. HCl / 24 h / Heating

2: acetic acid; NaBH₄ / methanol / 20 °C

With hydrogenchloride; sodium tetrahydroborate; acetic acid; In methanol;
DOI:10.1007/s00706-003-0152-8