4-methoxyphenyl 3-bromopropiolate

Base Information

• Chemical Name: 4-methoxyphenyl 3-bromopropiolate
• CAS No.: 1300060-08-5
• Molecular Formula: C₁₀H₇BrO₃
• Molecular Weight: 255.068
• Mol file: 1300060-08-5.mol

Synonyms:4-methoxyphenyl 3-bromopropiolate

Chemical Property of 4-methoxyphenyl 3-bromopropiolate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 4-methoxyphenyl 3-bromopropiolate

There total 2 articles about 4-methoxyphenyl 3-bromopropiolate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

4-methoxyphenyl propynoate (90920-97-1) → 4-methoxyphenyl 3-bromopropiolate (1300060-08-5)

Guidance literature:

With N-Bromosuccinimide; silver nitrate; In acetone; at 20 ℃; for 0.0833333h; Schlenk technique;

DOI:10.1021/ol503022h

Reference yield:

4-methoxy-phenol (150-76-5) → 4-methoxyphenyl 3-bromopropiolate (1300060-08-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: diisopropyl-carbodiimide / dichloromethane / 1 h / 0 °C / Schlenk technique

1.2: 0 °C / Schlenk technique

2.1: silver nitrate; N-Bromosuccinimide / acetone / 0.08 h / 20 °C / Schlenk technique

With N-Bromosuccinimide; silver nitrate; diisopropyl-carbodiimide; In dichloromethane; acetone;

DOI:10.1021/ol503022h

Reference yield: 85.0%

trifluorormethanesulfonic acid (1493-13-6) + 4-methoxyphenyl 3-bromopropiolate (1300060-08-5) + 1,3,9,11-tetramethyl-5λ3,7λ3-dibenzo[d,f][1,3,2]diiodaoxepine-5,7-diyl diacetate (1257076-22-4) → C48H34F6I2O12S2

Guidance literature:

In 2,2,2-trifluoroethanol; water; at 20 ℃; for 3h;

DOI:10.1002/anie.201007640

upstream raw materials:

4-methoxy-phenol

4-methoxyphenyl propynoate