2-Propynoic acid, 4-methoxyphenyl ester

Base Information

• Chemical Name: 2-Propynoic acid, 4-methoxyphenyl ester
• CAS No.: 90920-97-1
• Molecular Formula: C10H8O3
• Molecular Weight: 176.172
• Mol file: 90920-97-1.mol

Synonyms:

Chemical Property of 2-Propynoic acid, 4-methoxyphenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Propynoic acid, 4-methoxyphenyl ester

There total 2 articles about 2-Propynoic acid, 4-methoxyphenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

4-methoxy-phenol (150-76-5) + Propiolic acid (471-25-0) → 4-methoxyphenyl propynoate (90920-97-1) + 4-methoxyphenyl (E)-3-(4-methoxyphenoxy)acrylate (323208-04-4)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 24h;

DOI:10.1080/00397910008087068

Reference yield:

→ 4-methoxyphenyl propynoate (90920-97-1)

Guidance literature:

4-Methoxy-phenol in wss. NaOH, Propiolsaeure-chlorid in Bzl.;

Reference yield: 100.0%

4-methoxyphenyl propynoate (90920-97-1) → 6-methoxycoumarin (17372-53-1)

Guidance literature:

With Echavarren's catalyst; In dichloromethane; at 18 ℃; for 1h;

DOI:10.1021/acs.joc.0c02011

upstream raw materials:

4-methoxy-phenol

Propiolic acid

Downstream raw materials:

6-methoxy-chromen-4-one

6-methoxycoumarin

4-methoxyphenyl 3-bromopropiolate