3-(3'-benzyl-4''-(cyanomethoxy)-2,3''-diisobutyl-1,1':4',1''-terphenyl-4-yl)propanenitrile

Base Information

Chemical Name:3-(3'-benzyl-4''-(cyanomethoxy)-2,3''-diisobutyl-1,1':4',1''-terphenyl-4-yl)propanenitrile
CAS No.:475272-35-6
Molecular Formula:C₃₈H₄₀N₂O
Molecular Weight:540.748
Hs Code.:

Synonyms:3-(3'-benzyl-4''-(cyanomethoxy)-2,3''-diisobutyl-1,1':4',1''-terphenyl-4-yl)propanenitrile

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Chemical Property of 3-(3'-benzyl-4''-(cyanomethoxy)-2,3''-diisobutyl-1,1':4',1''-terphenyl-4-yl)propanenitrile

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Technology Process of 3-(3'-benzyl-4''-(cyanomethoxy)-2,3''-diisobutyl-1,1':4',1''-terphenyl-4-yl)propanenitrile

There total 12 articles about 3-(3'-benzyl-4''-(cyanomethoxy)-2,3''-diisobutyl-1,1':4',1''-terphenyl-4-yl)propanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.43%

: 475272-34-5
3-(3'-benzyl-2,3''-4''-hydroxy-diisobutyl-1,1':4',1''-terphenyl-4-yl)propanenitrile

: 107-14-2
chloroacetonitrile

: 475272-35-6
3-(3'-benzyl-4''-(cyanomethoxy)-2,3''-diisobutyl-1,1':4',1''-terphenyl-4-yl)propanenitrile

Guidance literature:: With potassium carbonate; In acetone; at 55 ℃; for 40h;
DOI:10.1021/ja026861k

Reference yield:

: 475272-19-6
3-(3'-benzyl-4'-hydroxy-2-isobutyl-1,1'-biphenyl-4-yl)propanenitrile

: 475272-35-6
3-(3'-benzyl-4''-(cyanomethoxy)-2,3''-diisobutyl-1,1':4',1''-terphenyl-4-yl)propanenitrile

Guidance literature:: Multi-step reaction with 4 steps

1: DIEA / CH₂Cl₂

2: Cs₂CO₃ / Pd(PPh₃)4 / dimethylformamide

3: BBr₃ / CH₂Cl₂

4: K₂CO₃ / acetone / 55 °C

With boron tribromide; potassium carbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; N,N-dimethyl-formamide; acetone; 2: Suzuki coupling;
DOI:10.1002/anie.200462316

Reference yield:

: 475272-18-5
3-(3'-benzyl-2-isobutyl-4'-methoxy-1,1'-biphenyl-4-yl)propanenitrile

: 475272-35-6
3-(3'-benzyl-4''-(cyanomethoxy)-2,3''-diisobutyl-1,1':4',1''-terphenyl-4-yl)propanenitrile

Guidance literature:: Multi-step reaction with 5 steps

1: BBr₃ / CH₂Cl₂ / 0 - 20 °C

2: DIEA / CH₂Cl₂

3: Cs₂CO₃ / Pd(PPh₃)4 / dimethylformamide

4: BBr₃ / CH₂Cl₂

5: K₂CO₃ / acetone / 55 °C

With boron tribromide; potassium carbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; N,N-dimethyl-formamide; acetone; 3: Suzuki coupling;
DOI:10.1002/anie.200462316