Technology Process of 3-(3,6-dihydro-2H-pyran-4-yl)-2-methyl-1-(4-methylphenyl)-1H-pyrrolo[2,3-c]pyridine
There total 4 articles about 3-(3,6-dihydro-2H-pyran-4-yl)-2-methyl-1-(4-methylphenyl)-1H-pyrrolo[2,3-c]pyridine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
potassium phosphate;
copper(l) iodide; N,N-dimethylethylenediamine;
In
N,N-dimethyl-formamide;
at 170 ℃;
for 9h;
Microwave irradiation;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: N-iodo-succinimide / chloroform / 2 h
2: dmap / dichloromethane
3: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 0.25 h / 160 °C / Microwave irradiation
4: potassium phosphate / copper(l) iodide; N,N-dimethylethylenediamine / N,N-dimethyl-formamide / 9 h / 170 °C / Microwave irradiation; Inert atmosphere
With
dmap; potassium phosphate; N-iodo-succinimide; sodium carbonate;
copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); N,N-dimethylethylenediamine;
In
1,4-dioxane; dichloromethane; chloroform; water; N,N-dimethyl-formamide;
3: Suzuki Coupling / 4: Buchwald-Hartwig Reaction;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: dmap / dichloromethane
2: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 0.25 h / 160 °C / Microwave irradiation
3: potassium phosphate / copper(l) iodide; N,N-dimethylethylenediamine / N,N-dimethyl-formamide / 9 h / 170 °C / Microwave irradiation; Inert atmosphere
With
dmap; potassium phosphate; sodium carbonate;
copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); N,N-dimethylethylenediamine;
In
1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;
2: Suzuki Coupling / 3: Buchwald-Hartwig Reaction;