{(R)-2-[2-((S)-1-Hydroxy-2,2-dimethyl-propyl)-4-oxo-4H-quinazolin-3-ylamino]-1-phenyl-ethyl}-carbamic acid tert-butyl ester

Base Information

Chemical Name:{(R)-2-[2-((S)-1-Hydroxy-2,2-dimethyl-propyl)-4-oxo-4H-quinazolin-3-ylamino]-1-phenyl-ethyl}-carbamic acid tert-butyl ester
CAS No.:312532-36-8
Molecular Formula:C₂₆H₃₄N₄O₄
Molecular Weight:466.58
Hs Code.:

Synonyms:{(R)-2-[2-((S)-1-Hydroxy-2,2-dimethyl-propyl)-4-oxo-4H-quinazolin-3-ylamino]-1-phenyl-ethyl}-carbamic acid tert-butyl ester

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Chemical Property of {(R)-2-[2-((S)-1-Hydroxy-2,2-dimethyl-propyl)-4-oxo-4H-quinazolin-3-ylamino]-1-phenyl-ethyl}-carbamic acid tert-butyl ester

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Technology Process of {(R)-2-[2-((S)-1-Hydroxy-2,2-dimethyl-propyl)-4-oxo-4H-quinazolin-3-ylamino]-1-phenyl-ethyl}-carbamic acid tert-butyl ester

There total 6 articles about {(R)-2-[2-((S)-1-Hydroxy-2,2-dimethyl-propyl)-4-oxo-4H-quinazolin-3-ylamino]-1-phenyl-ethyl}-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 201730-82-7
3-((R)-2-Azido-2-phenyl-ethylamino)-2-((S)-1-hydroxy-2,2-dimethyl-propyl)-3H-quinazolin-4-one

: 312532-36-8
{(R)-2-[2-((S)-1-Hydroxy-2,2-dimethyl-propyl)-4-oxo-4H-quinazolin-3-ylamino]-1-phenyl-ethyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / 5percent Pd/C / ethyl acetate / 48 h

2: 206 mg / Et₃N / tetrahydrofuran; H₂O / 0.75 h / 20 °C

With hydrogen; triethylamine; 5percent Pd/C; In tetrahydrofuran; water; ethyl acetate; 1: Catalytic hydrogenation / 2: Acylation;
DOI:10.1039/b004798h

Reference yield:

: 182160-14-1
2-((S)-1-Hydroxy-2,2-dimethyl-propyl)-3-((S)-2-phenyl-aziridin-1-yl)-3H-quinazolin-4-one

: 312532-36-8
{(R)-2-[2-((S)-1-Hydroxy-2,2-dimethyl-propyl)-4-oxo-4H-quinazolin-3-ylamino]-1-phenyl-ethyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / NaN₃, AcOH / dimethylsulfoxide / 70 °C

2: hydrogen / Pd/C

With sodium azide; hydrogen; acetic acid; palladium on activated charcoal; In dimethyl sulfoxide;
DOI:10.1016/S0040-4039(97)10586-X

Reference yield:

: 201730-83-8
3-((R)-2-Chloro-2-phenyl-ethylamino)-2-((S)-1-hydroxy-2,2-dimethyl-propyl)-3H-quinazolin-4-one

: 312532-36-8
{(R)-2-[2-((S)-1-Hydroxy-2,2-dimethyl-propyl)-4-oxo-4H-quinazolin-3-ylamino]-1-phenyl-ethyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 99 percent / NaH / tetrahydrofuran / 1.17 h / 20 °C

2: 94 percent / NaN₃; AcOH / dimethylsulfoxide / 17 h / 70 °C

3: H₂ / 5percent Pd/C / ethyl acetate / 48 h

4: 206 mg / Et₃N / tetrahydrofuran; H₂O / 0.75 h / 20 °C

With sodium azide; hydrogen; sodium hydride; acetic acid; triethylamine; 5percent Pd/C; In tetrahydrofuran; water; dimethyl sulfoxide; ethyl acetate; 1: Cyclization / 2: Ring cleavage / 3: Catalytic hydrogenation / 4: Acylation;
DOI:10.1039/b004798h