[(1R)-2-AMINO-1-PHENYLETHYL]-CARBAMIC ACID 1,1-DIMETHYLETHYL ESTER

Base Information

• Chemical Name: [(1R)-2-AMINO-1-PHENYLETHYL]-CARBAMIC ACID 1,1-DIMETHYLETHYL ESTER
• CAS No.: 137102-65-9
• Molecular Formula: C13H20N2O2
• Molecular Weight: 236.314
• Hs Code.: 2924297099
• Mol file: 137102-65-9.mol

Synonyms:(R)-(-)-1-[(butoxycarbonyl)amino]-1-phenyleth-2-ylamine;tert-butyl ((1R)-2-amino-1-phenethyl)carbamate;tert-butyl (R)-N-(2-amino-1-phenylethyl)carbamate;((R)-2-AMINO-1-PHENYL-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER;tert-butyl (R)-2-amino-1-phenylethylcarbamate;(R)-2-(Boc-amino)-2-phenylethylamine;(R)-TERT-BUTYL 2-AMINO-1-PHENYLETHYLCARBAMATE;[(1R)-2-AMINO-1-PHENYLETHYL]-CARBAMIC ACID 1,1-DIMETHYLETHYL ESTER;

Chemical Property of [(1R)-2-AMINO-1-PHENYLETHYL]-CARBAMIC ACID 1,1-DIMETHYLETHYL ESTER

Chemical Property:

• Boiling Point: 372.2±35.0 °C(Predicted)
• PKA: 11?+-.0.46(Predicted)
• PSA: 67.84000
• Density: 1.066±0.06 g/cm3(Predicted)
• LogP: 3.11580

Purity/Quality:

98%min ^*data from raw suppliers

(R)-2-(Boc-amino)-2-phenylethylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of [(1R)-2-AMINO-1-PHENYLETHYL]-CARBAMIC ACID 1,1-DIMETHYLETHYL ESTER

There total 25 articles about [(1R)-2-AMINO-1-PHENYLETHYL]-CARBAMIC ACID 1,1-DIMETHYLETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(R)-N-(tert-butoxycarbonyl)phenylglycinol (67341-01-9,117049-14-6,138457-46-2,102089-74-7) → (R)-(2-amino-1-phenyl-ethyl)-carbamic acid tert-butyl ester (137102-65-9,142910-85-8)

Guidance literature:

With phthalimide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 20 ℃; for 6h; Cooling with ice;

Reference yield: 96.0%

(R)-(-)-1-<(butoxycarbonyl)amino>-1-phenylethyl azide (134557-76-9) → (R)-(2-amino-1-phenyl-ethyl)-carbamic acid tert-butyl ester (137102-65-9,142910-85-8)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 10h;

DOI:10.1016/j.bmcl.2005.05.038

Reference yield: 94.0%

tert-butyl [(1R)-2-nitro-1-phenylethyl]carbamate (685132-79-0) → (R)-(2-amino-1-phenyl-ethyl)-carbamic acid tert-butyl ester (137102-65-9,142910-85-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃;

DOI:10.1002/anie.200502674

upstream raw materials:

(R)-(-)-1-<(butoxycarbonyl)amino>-1-phenylethyl azide

{(R)-2-[2-((S)-1-Hydroxy-2,2-dimethyl-propyl)-4-oxo-4H-quinazolin-3-ylamino]-1-phenyl-ethyl}-carbamic acid tert-butyl ester

tert-butyl [(1R)-2-nitro-1-phenylethyl]carbamate

(R)-tert-butyl (2-(1,3-dioxoisoindolin-2-yl)-1-phenylethyl)carbamate

Refernces

• 1、 Skepper, Colin K.,Moreau, Robert J.,Appleton, Brent A.,Benton, Bret M.,Drumm, Joseph E.,Feng, Brian Y.,Geng, Mei,Hu, Cheng,Li, Cindy,Lingel, Andreas,Lu, Yipin,Mamo, Mulugeta,Mergo, Wosenu,Mostafavi, Mina,Rath, Christopher M.,Steffek, Micah,Takeoka, Kenneth T.,Uehara, Kyoko,Wang, Lisha,Wei, Jun-Rong,Xie, Lili,Xu, Wenjian,Zhang, Qiong,De Vicente, Javier. "Discovery and Optimization of Phosphopantetheine Adenylyltransferase Inhibitors with Gram-Negative Antibacterial Activity". supporting information. p. 3325 - 3349. Retrieved 2018/05/01.
• 2、 -. "SONIC HEDGEHOG MODULATORS". Paragraph 1137. . Retrieved 2014/04/17.