(R)-tert-butyl (2-amino-1-phenylethyl)carbamate

Base Information

• Chemical Name: (R)-tert-butyl (2-amino-1-phenylethyl)carbamate
• CAS No.: 137102-65-9
• Molecular Formula: C13H20N2O2
• Molecular Weight: 236.314
• Hs Code.: 2924297099
• European Community (EC) Number: 886-581-9
• Nikkaji Number: J2.291.041H
• Mol file: 137102-65-9.mol

Synonyms:137102-65-9;(R)-2-(Boc-amino)-2-phenylethylamine;(R)-tert-butyl (2-amino-1-phenylethyl)carbamate;tert-butyl N-[(1R)-2-amino-1-phenylethyl]carbamate;[(1R)-2-AMINO-1-PHENYLETHYL]-CARBAMIC ACID 1,1-DIMETHYLETHYL ESTER;SCHEMBL3755737;IJALRZPKODHZOR-NSHDSACASA-N;CS-0433178;C77879;(R)-tert-butyl(2-amino-1-phenylethyl)carbamate;EN300-7337082;((R)-2-AMINO-1-PHENYL-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER

Chemical Property of (R)-tert-butyl (2-amino-1-phenylethyl)carbamate

Chemical Property:

• Boiling Point: 372.2±35.0 °C(Predicted)
• PKA: 11?+-.0.46(Predicted)
• PSA: 67.84000
• Density: 1.066±0.06 g/cm3(Predicted)
• LogP: 3.11580
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 236.152477885
• Heavy Atom Count: 17
• Complexity: 242

Purity/Quality:

98%min ^*data from raw suppliers

(R)-2-(Boc-amino)-2-phenylethylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)NC(CN)C1=CC=CC=C1
• Isomeric SMILES: CC(C)(C)OC(=O)N[C@@H](CN)C1=CC=CC=C1

Technology Process of (R)-tert-butyl (2-amino-1-phenylethyl)carbamate

There total 25 articles about (R)-tert-butyl (2-amino-1-phenylethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(R)-N-(tert-butoxycarbonyl)phenylglycinol (67341-01-9,117049-14-6,138457-46-2,102089-74-7) → (R)-(2-amino-1-phenyl-ethyl)-carbamic acid tert-butyl ester (137102-65-9,142910-85-8)

Guidance literature:

With phthalimide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 20 ℃; for 6h; Cooling with ice;

Reference yield: 96.0%

(R)-(-)-1-<(butoxycarbonyl)amino>-1-phenylethyl azide (134557-76-9) → (R)-(2-amino-1-phenyl-ethyl)-carbamic acid tert-butyl ester (137102-65-9,142910-85-8)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 10h;

DOI:10.1016/j.bmcl.2005.05.038

Reference yield: 94.0%

tert-butyl [(1R)-2-nitro-1-phenylethyl]carbamate (685132-79-0) → (R)-(2-amino-1-phenyl-ethyl)-carbamic acid tert-butyl ester (137102-65-9,142910-85-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃;

DOI:10.1002/anie.200502674

upstream raw materials:

(R)-(-)-1-<(butoxycarbonyl)amino>-1-phenylethyl azide

{(R)-2-[2-((S)-1-Hydroxy-2,2-dimethyl-propyl)-4-oxo-4H-quinazolin-3-ylamino]-1-phenyl-ethyl}-carbamic acid tert-butyl ester

tert-butyl [(1R)-2-nitro-1-phenylethyl]carbamate

(R)-tert-butyl (2-(1,3-dioxoisoindolin-2-yl)-1-phenylethyl)carbamate

Downstream raw materials:

(R)-(-)-N-<2-<<<2,6-bis(1-methylethyl)phenoxy>carbonyl>amino>-1-phenylethyl>carbamic acid 1,1-dimethylethyl ester

(R)-(-)-N-<2,6-bis(1-methylethyl)phenyl>-N'-<2-<(butoxycarbonyl)amino>-2-phenylethyl>urea

[2-(3-bromo-benzoylamino)-1-phenyl-ethyl]-carbamic acid tert-butyl ester

{2-[3-(2-fluoro-3-methoxy-phenyl)-ureido]-1-phenyl-ethyl}-carbamic acid tert-butyl ester