syn-1-[N-(tert-butoxycarbonyl)amino]-3-benzyloxymethyl-1-cyclobutane-1-carboxylic acid

Base Information

Chemical Name:syn-1-[N-(tert-butoxycarbonyl)amino]-3-benzyloxymethyl-1-cyclobutane-1-carboxylic acid
CAS No.:439090-01-4
Molecular Formula:C₁₈H₂₅NO₅
Molecular Weight:335.4
Hs Code.:

Synonyms:syn-1-[N-(tert-butoxycarbonyl)amino]-3-benzyloxymethyl-1-cyclobutane-1-carboxylic acid

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Chemical Property of syn-1-[N-(tert-butoxycarbonyl)amino]-3-benzyloxymethyl-1-cyclobutane-1-carboxylic acid

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Technology Process of syn-1-[N-(tert-butoxycarbonyl)amino]-3-benzyloxymethyl-1-cyclobutane-1-carboxylic acid

There total 4 articles about syn-1-[N-(tert-butoxycarbonyl)amino]-3-benzyloxymethyl-1-cyclobutane-1-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1-amino-3-benzyloxymethyl-cyclobutanecarboxylic acid

: 439090-01-4
syn-1-[N-(tert-butoxycarbonyl)amino]-3-benzyloxymethyl-1-cyclobutane-1-carboxylic acid

Guidance literature:: DOI:10.1002/jlcr.466

Reference yield:

: 172324-67-3
3-benzyloxymethyl-cyclobutanone

: 439090-01-4
syn-1-[N-(tert-butoxycarbonyl)amino]-3-benzyloxymethyl-1-cyclobutane-1-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 50 percent / aq. (NH₄)2CO₃; aq. NH₄Cl / ethanol / 72 h / 60 °C

2: aq. NaOH / 12 h / 120 °C

3: Et₃N / methanol / 12 h / 20 °C

With sodium hydroxide; ammonium carbonate; ammonium chloride; triethylamine; In methanol; ethanol;
DOI:10.1021/jm010242p

Reference yield:

: 421580-30-5
syn-2-[(benzyloxy)methyl]-5,7-diazaspiro[3.4]octane-6,8-dione

: 439090-01-4
syn-1-[N-(tert-butoxycarbonyl)amino]-3-benzyloxymethyl-1-cyclobutane-1-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: aq. NaOH / 12 h / 120 °C

2: Et₃N / methanol / 12 h / 20 °C

With sodium hydroxide; triethylamine; In methanol;
DOI:10.1021/jm010242p