6-CHLORO-3-HYDROXY (1H)INDAZOLE

Base Information

• Chemical Name: 6-CHLORO-3-HYDROXY (1H)INDAZOLE
• CAS No.: 7364-29-6
• Molecular Formula: C7H5ClN2O
• Molecular Weight: 168.58
• Hs Code.: 2933990090
• Mol file: 7364-29-6.mol

Synonyms:3-Indazolinone,6-chloro- (7CI,8CI);6-Chloro-1H-indazol-3-ol;6-Chloro-3-indazolinone;1H-indazol-3-ol, 6-chloro-;

Chemical Property of 6-CHLORO-3-HYDROXY (1H)INDAZOLE

Chemical Property:

• Vapor Pressure: 6.1E-07mmHg at 25°C
• Refractive Index: 1.759
• Boiling Point: 399.1 °C at 760 mmHg
• Flash Point: 195.2 °C
• PSA: 48.91000
• Density: 1.598 g/cm³
• LogP: 1.92190

Purity/Quality:

99.5% ^*data from raw suppliers

6-Chloro-3-hydroxy-(1H)-indazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-CHLORO-3-HYDROXY (1H)INDAZOLE

There total 6 articles about 6-CHLORO-3-HYDROXY (1H)INDAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2-Amino-4-chlorobenzoic acid (89-77-0) → 6-chloro-1H-indazol-3-ol (7364-29-6)

Guidance literature:

2-Amino-4-chlorobenzoic acid; With hydrogenchloride; sodium nitrite; at 0 ℃; for 0.5h;

With sodium sulfite; at 20 ℃; for 2h;

With hydrogenchloride; at 20 - 80 ℃;

DOI:10.1021/jm030638w

Reference yield:

4-Chloro-2-hydrazino-benzoic acid (299166-41-9) → 6-chloro-1H-indazol-3-ol (7364-29-6)

Guidance literature:

With hydrogenchloride; In water; at 80 ℃;

DOI:10.1016/j.bmcl.2007.08.041

Reference yield:

2-Amino-4-chlorobenzoic acid (89-77-0) → 6-Chlorindazolin-3-on (7364-29-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) aq. HCl, NaNO₂, 2.) Na₂SO₃ / 1.) <10 deg C, 30 min, 2.) H₂O, RT, 2 h

2: conc. HCl / a) RT, overnight, b) 80 deg C, 6 h

With hydrogenchloride; sodium sulfite; sodium nitrite;

DOI:10.1021/jm00372a011

upstream raw materials:

4-Chloro-2-hydrazino-benzoic acid; hydrochloride

2-Amino-4-chlorobenzoic acid

4-Chloro-2-hydrazino-benzoic acid

Downstream raw materials:

6-Chloro-3-oxo-2,3-dihydro-indazole-1-carboxylic acid ethyl ester

Refernces

• 1、 Stiff, Cory,Graber, David R.,Thorarensen, Atli,Wakefield, Brian D.,Marotti, Keith R.,Melchior, Earline P.,Sweeney, Michael T.,Han, Fusen,Rohrer, Douglas C.,Zurenko, Gary E.,Romero, Donna L.. "Bacterial translation inhibitors, 1-acylindazol-3-ols as anthranilic acid mimics". scheme or table. p. 6293 - 6297. Retrieved 2009/07/18.
• 2、 -. "NOVEL ARYL UREIDO BENZOIC ACID DERIVATIVES AND THEIR USE". Page 21. . Retrieved 2008/06/13.