((R)-6-iodo-1,2,3,4-tetrahydro-naphthalen-1-ylmethyl)-carbamic acid benzyl ester

Base Information

Chemical Name:((R)-6-iodo-1,2,3,4-tetrahydro-naphthalen-1-ylmethyl)-carbamic acid benzyl ester
CAS No.:1000300-17-3
Molecular Formula:C₁₉H₂₀INO₂
Molecular Weight:421.278
Hs Code.:

Synonyms:((R)-6-iodo-1,2,3,4-tetrahydro-naphthalen-1-ylmethyl)-carbamic acid benzyl ester

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Chemical Property of ((R)-6-iodo-1,2,3,4-tetrahydro-naphthalen-1-ylmethyl)-carbamic acid benzyl ester

Chemical Property:

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Technology Process of ((R)-6-iodo-1,2,3,4-tetrahydro-naphthalen-1-ylmethyl)-carbamic acid benzyl ester

There total 4 articles about ((R)-6-iodo-1,2,3,4-tetrahydro-naphthalen-1-ylmethyl)-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: (R)-C-(6-iodo-1,2,3,4-tetrahydro-naphthalen-1-yl)-methylamine hydrochloride

: 501-53-1,94274-21-2
benzyl chloroformate

: 1000300-17-3
((R)-6-iodo-1,2,3,4-tetrahydro-naphthalen-1-ylmethyl)-carbamic acid benzyl ester

Guidance literature:: With sodium carbonate; In water; toluene; at 23 ℃; for 2h;

Reference yield:

: 88611-67-0
6-acetamido-1,2,3,4-tetrahydronaphthalen-1-one

: 1000300-17-3
((R)-6-iodo-1,2,3,4-tetrahydro-naphthalen-1-ylmethyl)-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: sulfuric acid / water / 0.75 h / 90 °C

2.1: acetic acid; sodium nitrite / water / 0.5 h / 0 °C

3.1: borane N,N-diethylaniline complex; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / toluene / 3 h / 30 °C

3.2: 0.25 h / 20 °C

4.1: di-isopropyl azodicarboxylate; trimethylphosphane / toluene / 0.5 h / -50 °C

5.1: methanol; sodium hydroxide; water / 20 h / Heating / reflux

5.2: 2 h / Heating / reflux

6.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 23 °C

7.1: sodium azide / water; acetone / 0.5 h / 0 °C

7.2: 0.67 h / Heating / reflux

8.1: sodium carbonate / water; toluene / 2 h / 23 °C

With methanol; sodium hydroxide; borane N,N-diethylaniline complex; sodium azide; oxalyl dichloride; di-isopropyl azodicarboxylate; sulfuric acid; water; sodium carbonate; acetic acid; N,N-dimethyl-formamide; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; sodium nitrite; trimethylphosphane; In dichloromethane; water; acetone; toluene;

Reference yield:

: 340825-13-0
6-iodo-3,4-dihydro-2H-naphthalen-1-one

: 1000300-17-3
((R)-6-iodo-1,2,3,4-tetrahydro-naphthalen-1-ylmethyl)-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: borane N,N-diethylaniline complex; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / toluene / 3 h / 30 °C

1.2: 0.25 h / 20 °C

2.1: di-isopropyl azodicarboxylate; trimethylphosphane / toluene / 0.5 h / -50 °C

3.1: methanol; sodium hydroxide; water / 20 h / Heating / reflux

3.2: 2 h / Heating / reflux

4.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 23 °C

5.1: sodium azide / water; acetone / 0.5 h / 0 °C

5.2: 0.67 h / Heating / reflux

6.1: sodium carbonate / water; toluene / 2 h / 23 °C

With methanol; sodium hydroxide; borane N,N-diethylaniline complex; sodium azide; oxalyl dichloride; di-isopropyl azodicarboxylate; water; sodium carbonate; N,N-dimethyl-formamide; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; trimethylphosphane; In dichloromethane; water; acetone; toluene;