5-bromo-4-(4-chlorobenzyl)-7-fluoro-1,4-dihydrocyclopenta[b]indol-3(2H)-one

Base Information

Chemical Name:5-bromo-4-(4-chlorobenzyl)-7-fluoro-1,4-dihydrocyclopenta[b]indol-3(2H)-one
CAS No.:869194-32-1
Molecular Formula:C₁₈H₁₂BrClFNO
Molecular Weight:392.655
Hs Code.:

Synonyms:5-bromo-4-(4-chlorobenzyl)-7-fluoro-1,4-dihydrocyclopenta[b]indol-3(2H)-one

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Chemical Property of 5-bromo-4-(4-chlorobenzyl)-7-fluoro-1,4-dihydrocyclopenta[b]indol-3(2H)-one

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Technology Process of 5-bromo-4-(4-chlorobenzyl)-7-fluoro-1,4-dihydrocyclopenta[b]indol-3(2H)-one

There total 3 articles about 5-bromo-4-(4-chlorobenzyl)-7-fluoro-1,4-dihydrocyclopenta[b]indol-3(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 869194-30-9
5-bromo-7-fluoro-1,4-dihydrocyclopenta[b]indol-3(2H)-one

: 104-83-6
1-Chloro-4-(chloromethyl)benzene

: 869194-32-1
5-bromo-4-(4-chlorobenzyl)-7-fluoro-1,4-dihydrocyclopenta[b]indol-3(2H)-one

Guidance literature:: With sodium hydroxide; tetrabutylammomium bromide; In tetrahydrofuran; at 50 ℃; for 22h;
DOI:10.1021/jo051146p

Reference yield:

: 1003-98-1
2-bromo-4-fluoroaniline

: 869194-32-1
5-bromo-4-(4-chlorobenzyl)-7-fluoro-1,4-dihydrocyclopenta[b]indol-3(2H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium nitrite; hydrogenchloride / water / 1 h / 0 °C

1.2: 2 h / 0 °C

1.3: 6 h / Reflux; Inert atmosphere

2.1: sodium hydroxide; tetrabutylammomium bromide / water; tetrahydrofuran / 6 h / Reflux

With hydrogenchloride; tetrabutylammomium bromide; sodium hydroxide; sodium nitrite; In tetrahydrofuran; water; 1.3: |Fischer Indole Synthesis;
DOI:10.1007/s00044-015-1431-8

Reference yield:

: 1192-54-7
2-formylcyclopentanone

: 869194-32-1
5-bromo-4-(4-chlorobenzyl)-7-fluoro-1,4-dihydrocyclopenta[b]indol-3(2H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium nitrite; hydrogenchloride / water / 1 h / 0 °C

1.2: 2 h / 0 °C

1.3: 6 h / Reflux; Inert atmosphere

2.1: sodium hydroxide; tetrabutylammomium bromide / water; tetrahydrofuran / 6 h / Reflux

With hydrogenchloride; tetrabutylammomium bromide; sodium hydroxide; sodium nitrite; In tetrahydrofuran; water; 1.3: |Fischer Indole Synthesis;
DOI:10.1007/s00044-015-1431-8