(R)-2-(5-broMo-4-(4-chlorobenzyl)-7-fluoro-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid

Base Information

Chemical Name:(R)-2-(5-broMo-4-(4-chlorobenzyl)-7-fluoro-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid
CAS No.:393509-05-2
Molecular Formula:C20H16BrClFNO2
Molecular Weight:436.708
Hs Code.:

Synonyms:(R)-2-(5-broMo-4-(4-chlorobenzyl)-7-fluoro-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid

Suppliers and Price of (R)-2-(5-broMo-4-(4-chlorobenzyl)-7-fluoro-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of (R)-2-(5-broMo-4-(4-chlorobenzyl)-7-fluoro-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid

Chemical Property:

Purity/Quality:: 98%,99%, ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-2-(5-broMo-4-(4-chlorobenzyl)-7-fluoro-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid

There total 23 articles about (R)-2-(5-broMo-4-(4-chlorobenzyl)-7-fluoro-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 393509-04-1
[5-bromo-4-(4-chlorobenzyl)-7-fluoro-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]acetic acid

: 393509-05-2
[(3R)-5-bromo-4-(4-chlorobenzyl)-7-fluoro-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]acetic acid

Guidance literature:: [5-bromo-4-(4-chlorobenzyl)-7-fluoro-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]acetic acid; With (S)-1-(1-Naphthyl)ethylamine; In ethanol; at 20 - 80 ℃;

With hydrogenchloride; In water;

Reference yield:

: 923580-07-8
(2E)-[5-bromo-4-(4-chlorobenzyl)-7-fluoro-1,4-dihydrocyclopenta[b]indol-3(2H)-ylidene]acetic acid

: [4-(4-chlorobenzyl)-7-fluoro-5-bromo-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]acetic acid

: 393509-05-2
[(3R)-5-bromo-4-(4-chlorobenzyl)-7-fluoro-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]acetic acid

Guidance literature:: With 1,1'-bis[(S)-4,5-dihydro-3H-binaphtho[2,1-c:1',2'-e]phosphino]ferrocene; hydrogen; triethylamine; Rh(cod)3⁽¹⁺⁾*BF₄^(1-); In methanol; at 50 ℃; for 20h; under 5430.05 Torr; Title compound not separated from byproducts;
DOI:10.1021/ja0623358

Reference yield:

: 20826-94-2
ethyl (2-oxocyclopentyl)acetate

: 393509-05-2
[(3R)-5-bromo-4-(4-chlorobenzyl)-7-fluoro-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]acetic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: p-TsOH*H₂O / toluene / 20 h / Heating

2.1: 252 g / nBu₄NCl / Pd(OAc)2 / dimethylformamide / 1 h / 80 °C

3.1: 92 percent / aq. NaOH / tetrahydrofuran; methanol / 0.25 h / 60 °C

4.1: pyridinium tribromide; pyridine / 0.75 h / -30 - 20 °C

5.1: 117 g / AcOH; Zn / 1 h / 20 °C

6.1: HCl

7.1: NaH / dimethylformamide / 0.33 h / 0 °C

7.2: dimethylformamide / 0.42 h / -50 - 0 °C

8.1: 74.1 g / aq. NaOH / tetrahydrofuran; methanol / 0.25 h / 60 °C

9.1: 42 percent / (S)-(-)-1-(1-naphthyl)ethylamine salt / methanol

With pyridine; hydrogenchloride; sodium hydroxide; (S)-(-)-1-(1-naphthyl)ethylamine salt; tetrabutyl-ammonium chloride; sodium hydride; toluene-4-sulfonic acid; acetic acid; pyridinium hydrobromide perbromide; zinc; palladium diacetate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm0603668