(R)-3-(((1R,4R)-1-(hydroxymethyl)-5,7,8-trimethoxy-2-(4-methoxybenzyl)-6-methyl-3-oxo-1,2,3,4-tetrahydroisoquinolin-4-yl)thio)-2-(((2,2,2-trichloroethoxy)carbonyl)amino)propanoic acid

Base Information

Chemical Name:(R)-3-(((1R,4R)-1-(hydroxymethyl)-5,7,8-trimethoxy-2-(4-methoxybenzyl)-6-methyl-3-oxo-1,2,3,4-tetrahydroisoquinolin-4-yl)thio)-2-(((2,2,2-trichloroethoxy)carbonyl)amino)propanoic acid
CAS No.:1339232-29-9
Molecular Formula:C₂₈H₃₃Cl₃N₂O₁₀S
Molecular Weight:696.002
Hs Code.:

(R)-3-(((1R,4R)-1-(hydroxymethyl)-5,7,8-trimethoxy-2-(4-methoxybenzyl)-6-methyl-3-oxo-1,2,3,4-tetrahydroisoquinolin-4-yl)thio)-2-(((2,2,2-trichloroethoxy)carbonyl)amino)propanoic acid

Synonyms:(R)-3-(((1R,4R)-1-(hydroxymethyl)-5,7,8-trimethoxy-2-(4-methoxybenzyl)-6-methyl-3-oxo-1,2,3,4-tetrahydroisoquinolin-4-yl)thio)-2-(((2,2,2-trichloroethoxy)carbonyl)amino)propanoic acid

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Chemical Property of (R)-3-(((1R,4R)-1-(hydroxymethyl)-5,7,8-trimethoxy-2-(4-methoxybenzyl)-6-methyl-3-oxo-1,2,3,4-tetrahydroisoquinolin-4-yl)thio)-2-(((2,2,2-trichloroethoxy)carbonyl)amino)propanoic acid

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Technology Process of (R)-3-(((1R,4R)-1-(hydroxymethyl)-5,7,8-trimethoxy-2-(4-methoxybenzyl)-6-methyl-3-oxo-1,2,3,4-tetrahydroisoquinolin-4-yl)thio)-2-(((2,2,2-trichloroethoxy)carbonyl)amino)propanoic acid

There total 20 articles about (R)-3-(((1R,4R)-1-(hydroxymethyl)-5,7,8-trimethoxy-2-(4-methoxybenzyl)-6-methyl-3-oxo-1,2,3,4-tetrahydroisoquinolin-4-yl)thio)-2-(((2,2,2-trichloroethoxy)carbonyl)amino)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1339232-84-6
(R)-methyl 3-(((1R,4R)-1-(hydroxymethyl)-5,7,8-trimethoxy-2-(4-methoxybenzyl)-6-methyl-3-oxo-1,2,3,4-tetrahydroisoquinolin-4-yl)thio)-2-(((2,2,2-trichloroethoxy)carbonyl)amino)propanoate

: 1339232-29-9
(R)-3-(((1R,4R)-1-(hydroxymethyl)-5,7,8-trimethoxy-2-(4-methoxybenzyl)-6-methyl-3-oxo-1,2,3,4-tetrahydroisoquinolin-4-yl)thio)-2-(((2,2,2-trichloroethoxy)carbonyl)amino)propanoic acid

Guidance literature:: With water; potassium carbonate; In methanol; at 20 ℃; for 4h; Inert atmosphere;
DOI:10.1039/c1cc13992d

Reference yield:

: C₂₈H₃₅N₃O₄Si

: 1339232-29-9
(R)-3-(((1R,4R)-1-(hydroxymethyl)-5,7,8-trimethoxy-2-(4-methoxybenzyl)-6-methyl-3-oxo-1,2,3,4-tetrahydroisoquinolin-4-yl)thio)-2-(((2,2,2-trichloroethoxy)carbonyl)amino)propanoic acid

Guidance literature:: Multi-step reaction with 10 steps

1: water; triphenylphosphine / tetrahydrofuran; water / 3 h / 60 °C / Inert atmosphere

2: methanol / 4 h / Inert atmosphere; Reflux

3: sodium tetrahydroborate / methanol / 2.5 h / 0 - 20 °C / Inert atmosphere

4: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

5: water; potassium carbonate / methanol / 17 h / 20 °C / Inert atmosphere

6: sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

7: dichloromethane / 16 h / 20 °C / Inert atmosphere

8: scandium tris(trifluoromethanesulfonate) / dichloromethane / 17 h / Inert atmosphere; Reflux

9: pyridine; hydrogen fluoride; water / acetonitrile / 0 - 20 °C / Inert atmosphere

10: water; potassium carbonate / methanol / 4 h / 20 °C / Inert atmosphere

With pyridine; sodium tetrahydroborate; hydrogen fluoride; water; sulfur trioxide pyridine complex; potassium carbonate; dimethyl sulfoxide; triethylamine; triphenylphosphine; scandium tris(trifluoromethanesulfonate); In tetrahydrofuran; methanol; dichloromethane; water; acetonitrile; 6: Parikh-Doering oxidation;
DOI:10.1039/c1cc13992d

Reference yield:

: 1339232-23-3
(R)-2-((tert-butyldiphenylsilyl)oxy)-1-(2,3,5-trimethoxy-4-methylphenyl)ethanamine

: 1339232-29-9
(R)-3-(((1R,4R)-1-(hydroxymethyl)-5,7,8-trimethoxy-2-(4-methoxybenzyl)-6-methyl-3-oxo-1,2,3,4-tetrahydroisoquinolin-4-yl)thio)-2-(((2,2,2-trichloroethoxy)carbonyl)amino)propanoic acid

Guidance literature:: Multi-step reaction with 9 steps

1: methanol / 4 h / Inert atmosphere; Reflux

2: sodium tetrahydroborate / methanol / 2.5 h / 0 - 20 °C / Inert atmosphere

3: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

4: water; potassium carbonate / methanol / 17 h / 20 °C / Inert atmosphere

5: sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

6: dichloromethane / 16 h / 20 °C / Inert atmosphere

7: scandium tris(trifluoromethanesulfonate) / dichloromethane / 17 h / Inert atmosphere; Reflux

8: pyridine; hydrogen fluoride; water / acetonitrile / 0 - 20 °C / Inert atmosphere

9: water; potassium carbonate / methanol / 4 h / 20 °C / Inert atmosphere

With pyridine; sodium tetrahydroborate; hydrogen fluoride; water; sulfur trioxide pyridine complex; potassium carbonate; dimethyl sulfoxide; triethylamine; scandium tris(trifluoromethanesulfonate); In methanol; dichloromethane; acetonitrile; 5: Parikh-Doering oxidation;
DOI:10.1039/c1cc13992d