2,2,2-trichloroethyl ((1R,4R,8R)-9,10,12-trimethoxy-13-(4-methoxybenzyl)-11-methyl-5,14-dioxo-1,3,4,5,7,8-hexahydro-8,1-(epiminomethano)benzo[g][1,5]oxathiecin-4-yl)carbamate

Base Information

Chemical Name:2,2,2-trichloroethyl ((1R,4R,8R)-9,10,12-trimethoxy-13-(4-methoxybenzyl)-11-methyl-5,14-dioxo-1,3,4,5,7,8-hexahydro-8,1-(epiminomethano)benzo[g][1,5]oxathiecin-4-yl)carbamate
CAS No.:1339231-97-8
Molecular Formula:C₂₈H₃₁Cl₃N₂O₉S
Molecular Weight:677.987
Hs Code.:

2,2,2-trichloroethyl ((1R,4R,8R)-9,10,12-trimethoxy-13-(4-methoxybenzyl)-11-methyl-5,14-dioxo-1,3,4,5,7,8-hexahydro-8,1-(epiminomethano)benzo[g][1,5]oxathiecin-4-yl)carbamate

Synonyms:2,2,2-trichloroethyl ((1R,4R,8R)-9,10,12-trimethoxy-13-(4-methoxybenzyl)-11-methyl-5,14-dioxo-1,3,4,5,7,8-hexahydro-8,1-(epiminomethano)benzo[g][1,5]oxathiecin-4-yl)carbamate

Suppliers and Price of 2,2,2-trichloroethyl ((1R,4R,8R)-9,10,12-trimethoxy-13-(4-methoxybenzyl)-11-methyl-5,14-dioxo-1,3,4,5,7,8-hexahydro-8,1-(epiminomethano)benzo[g][1,5]oxathiecin-4-yl)carbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2,2,2-trichloroethyl ((1R,4R,8R)-9,10,12-trimethoxy-13-(4-methoxybenzyl)-11-methyl-5,14-dioxo-1,3,4,5,7,8-hexahydro-8,1-(epiminomethano)benzo[g][1,5]oxathiecin-4-yl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2,2,2-trichloroethyl ((1R,4R,8R)-9,10,12-trimethoxy-13-(4-methoxybenzyl)-11-methyl-5,14-dioxo-1,3,4,5,7,8-hexahydro-8,1-(epiminomethano)benzo[g][1,5]oxathiecin-4-yl)carbamate

There total 21 articles about 2,2,2-trichloroethyl ((1R,4R,8R)-9,10,12-trimethoxy-13-(4-methoxybenzyl)-11-methyl-5,14-dioxo-1,3,4,5,7,8-hexahydro-8,1-(epiminomethano)benzo[g][1,5]oxathiecin-4-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1339232-29-9
(R)-3-(((1R,4R)-1-(hydroxymethyl)-5,7,8-trimethoxy-2-(4-methoxybenzyl)-6-methyl-3-oxo-1,2,3,4-tetrahydroisoquinolin-4-yl)thio)-2-(((2,2,2-trichloroethoxy)carbonyl)amino)propanoic acid

: 1339231-97-8
2,2,2-trichloroethyl ((1R,4R,8R)-9,10,12-trimethoxy-13-(4-methoxybenzyl)-11-methyl-5,14-dioxo-1,3,4,5,7,8-hexahydro-8,1-(epiminomethano)benzo[g][1,5]oxathiecin-4-yl)carbamate

Guidance literature:: With dmap; 2-methyl-6-nitrobenzoic anhydride; In dichloromethane; at 20 ℃; for 15h; Inert atmosphere;
DOI:10.1039/c1cc13992d

Reference yield:

: 1339232-76-6
(S)-2-((tert-butyldiphenylsilyl)oxy)-1-(2,3,5-trimethoxy-4-methylphenyl)ethanol

: 1339231-97-8
2,2,2-trichloroethyl ((1R,4R,8R)-9,10,12-trimethoxy-13-(4-methoxybenzyl)-11-methyl-5,14-dioxo-1,3,4,5,7,8-hexahydro-8,1-(epiminomethano)benzo[g][1,5]oxathiecin-4-yl)carbamate

Guidance literature:: Multi-step reaction with 12 steps

1: di-isopropyl azodicarboxylate; diphenyl phosphoryl azide; triphenylphosphine / tetrahydrofuran / 6 h / 0 °C / Inert atmosphere

2: water; triphenylphosphine / tetrahydrofuran; water / 3 h / 60 °C / Inert atmosphere

3: methanol / 4 h / Inert atmosphere; Reflux

4: sodium tetrahydroborate / methanol / 2.5 h / 0 - 20 °C / Inert atmosphere

5: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

6: water; potassium carbonate / methanol / 17 h / 20 °C / Inert atmosphere

7: sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

8: dichloromethane / 16 h / 20 °C / Inert atmosphere

9: scandium tris(trifluoromethanesulfonate) / dichloromethane / 17 h / Inert atmosphere; Reflux

10: pyridine; hydrogen fluoride; water / acetonitrile / 0 - 20 °C / Inert atmosphere

11: water; potassium carbonate / methanol / 4 h / 20 °C / Inert atmosphere

12: dmap; 2-methyl-6-nitrobenzoic anhydride / dichloromethane / 15 h / 20 °C / Inert atmosphere

With pyridine; dmap; sodium tetrahydroborate; di-isopropyl azodicarboxylate; diphenyl phosphoryl azide; 2-methyl-6-nitrobenzoic anhydride; hydrogen fluoride; water; sulfur trioxide pyridine complex; potassium carbonate; dimethyl sulfoxide; triethylamine; triphenylphosphine; scandium tris(trifluoromethanesulfonate); In tetrahydrofuran; methanol; dichloromethane; water; acetonitrile; 1: Mitsunobu reaction / 7: Parikh-Doering oxidation / 12: Pummerer type cyclisation;
DOI:10.1039/c1cc13992d

Reference yield:

: C₂₈H₃₅N₃O₄Si

: 1339231-97-8
2,2,2-trichloroethyl ((1R,4R,8R)-9,10,12-trimethoxy-13-(4-methoxybenzyl)-11-methyl-5,14-dioxo-1,3,4,5,7,8-hexahydro-8,1-(epiminomethano)benzo[g][1,5]oxathiecin-4-yl)carbamate

Guidance literature:: Multi-step reaction with 11 steps

1: water; triphenylphosphine / tetrahydrofuran; water / 3 h / 60 °C / Inert atmosphere

2: methanol / 4 h / Inert atmosphere; Reflux

3: sodium tetrahydroborate / methanol / 2.5 h / 0 - 20 °C / Inert atmosphere

4: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

5: water; potassium carbonate / methanol / 17 h / 20 °C / Inert atmosphere

6: sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

7: dichloromethane / 16 h / 20 °C / Inert atmosphere

8: scandium tris(trifluoromethanesulfonate) / dichloromethane / 17 h / Inert atmosphere; Reflux

9: pyridine; hydrogen fluoride; water / acetonitrile / 0 - 20 °C / Inert atmosphere

10: water; potassium carbonate / methanol / 4 h / 20 °C / Inert atmosphere

11: dmap; 2-methyl-6-nitrobenzoic anhydride / dichloromethane / 15 h / 20 °C / Inert atmosphere

With pyridine; dmap; sodium tetrahydroborate; 2-methyl-6-nitrobenzoic anhydride; hydrogen fluoride; water; sulfur trioxide pyridine complex; potassium carbonate; dimethyl sulfoxide; triethylamine; triphenylphosphine; scandium tris(trifluoromethanesulfonate); In tetrahydrofuran; methanol; dichloromethane; water; acetonitrile; 6: Parikh-Doering oxidation / 11: Pummerer type cyclisation;
DOI:10.1039/c1cc13992d