Di-tert-butyl pyrrolidine-3,4-diylbiscarbamate

Base Information

Chemical Name:Di-tert-butyl pyrrolidine-3,4-diylbiscarbamate
CAS No.:161723-00-8
Molecular Formula:C14H27 N3 O4
Molecular Weight:301.38
Hs Code.:
DSSTox Substance ID:DTXSID80594351
Mol file:161723-00-8.mol

Synonyms:Di-tert-butyl pyrrolidine-3,4-diylbiscarbamate;1824507-17-6;tert-Butyl N-(4-{[(tert-butoxy)carbonyl]amino}pyrrolidin-3-yl)carbamate;tert-butyl N-[4-[(2-methylpropan-2-yl)oxycarbonylamino]pyrrolidin-3-yl]carbamate;161723-00-8;SCHEMBL4643761;DTXSID80594351;EN300-366443;tert-ButylN-(4-{[(tert-butoxy)carbonyl]amino}pyrrolidin-3-yl)carbamate

Suppliers and Price of Di-tert-butyl pyrrolidine-3,4-diylbiscarbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
(R,R)-3,4-TRANS-(N-BOC)-DIAMINOPYRROLIDINE 95.00%
5G
$ 6852.04

American Custom Chemicals Corporation
(R,R)-3,4-TRANS-(N-BOC)-DIAMINOPYRROLIDINE 95.00%
1G
$ 3031.88

Total 10 raw suppliers

Chemical Property of Di-tert-butyl pyrrolidine-3,4-diylbiscarbamate

Chemical Property:

Boiling Point:433.8±45.0 °C(Predicted)
PKA:11.63±0.40(Predicted)
Density:1.10±0.1 g/cm3(Predicted)
XLogP3:1.1
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:301.20015635
Heavy Atom Count:21
Complexity:349

Purity/Quality:

99% ^*data from raw suppliers

(R,R)-3,4-TRANS-(N-BOC)-DIAMINOPYRROLIDINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)NC1CNCC1NC(=O)OC(C)(C)C

Technology Process of Di-tert-butyl pyrrolidine-3,4-diylbiscarbamate

There total 2 articles about Di-tert-butyl pyrrolidine-3,4-diylbiscarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 205251-35-0
N-benzyl-3,4-di(Boc-amino)pyrrolidine

: 161723-00-8
di-tert-butyl ((3R,4R)-pyrrolidine-3,4-diyl)dicarbamate

Guidance literature:: With hydrogen; palladium dihydroxide;
DOI:10.1002/(SICI)1521-3773(19980803)37:13/14<1846::AID-ANIE1846>3.0.CO;2-E

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 161723-00-8
di-tert-butyl ((3R,4R)-pyrrolidine-3,4-diyl)dicarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / CH₂Cl₂ / Ambient temperature

2: HCO₂NH₄ / Pd/C / methanol

With ammonium formate; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1016/S0960-894X(98)00063-8

Reference yield: 79.0%

: 161723-00-8
di-tert-butyl ((3R,4R)-pyrrolidine-3,4-diyl)dicarbamate

: (E)-4-(2-(ethyl(4-((4-nitrophenyl)diazenyl)phenyl)amino)ethoxy)-4-oxobutanoic acid

: 247048-25-5
4-((3R,4R)-3,4-Bis-tert-butoxycarbonylamino-pyrrolidin-1-yl)-4-oxo-butyric acid 2-{ethyl-[4-(4-nitro-phenylazo)-phenyl]-amino}-ethyl ester

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; at 0 ℃; for 2h; then 8 h at 25 deg C;
DOI:10.1016/0040-4020(94)00916-I