Technology Process of 20-epi-vitamin D3
There total 11 articles about 20-epi-vitamin D3 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen fluoride;
In
dichloromethane; acetonitrile;
at 20 ℃;
for 5h;
stereoselective reaction;
DOI:10.1002/chem.201705656
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: hydrogen fluoride / dichloromethane; acetonitrile / 24 h / 20 °C
2.1: dipyridinium dichromate / dichloromethane / 5 h / 20 °C
3.1: potassium tert-butylate / tetrahydrofuran; toluene / 2.25 h / -17 - 20 °C
3.2: 3.5 h / -17 - 20 °C
4.1: tricyclohexylphosphine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate / dimethyl sulfoxide / 2 h / 80 °C
5.1: bis-triphenylphosphine-palladium(II) chloride; caesium carbonate / water; benzene / 5 h / 20 °C
6.1: hydrogen fluoride / dichloromethane; acetonitrile / 5 h / 20 °C
With
bis-triphenylphosphine-palladium(II) chloride; dipyridinium dichromate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; hydrogen fluoride; potassium tert-butylate; potassium acetate; caesium carbonate; tricyclohexylphosphine;
In
tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; toluene; acetonitrile; benzene;
4.1: |Miyaura Borylation Reaction / 5.1: |Suzuki-Miyaura Coupling;
DOI:10.1002/chem.201705656
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: -78 °C
1.2: 4 h / -20 °C
2.1: bis-triphenylphosphine-palladium(II) chloride; caesium carbonate / water; benzene / 5 h / 20 °C
3.1: hydrogen fluoride / dichloromethane; acetonitrile / 5 h / 20 °C
With
bis-triphenylphosphine-palladium(II) chloride; hydrogen fluoride; caesium carbonate;
In
dichloromethane; water; acetonitrile; benzene;
2.1: |Suzuki-Miyaura Coupling;
DOI:10.1002/chem.201705656
