(1R,3aR,4S,7aR)-octahydro-4-[(1,1-dimethylethyl)dimethylsilyloxy]-1-[(R)-2-hydroxy-1-methylethyl]-7a-methyl-1H-indene

Base Information

• Chemical Name: (1R,3aR,4S,7aR)-octahydro-4-[(1,1-dimethylethyl)dimethylsilyloxy]-1-[(R)-2-hydroxy-1-methylethyl]-7a-methyl-1H-indene
• CAS No.: 171011-48-6
• Molecular Formula: C₁₉H₃₈O₂Si
• Molecular Weight: 326.595
• Mol file: 171011-48-6.mol

Synonyms:(1R,3aR,4S,7aR)-octahydro-4-[(1,1-dimethylethyl)dimethylsilyloxy]-1-[(R)-2-hydroxy-1-methylethyl]-7a-methyl-1H-indene

Chemical Property of (1R,3aR,4S,7aR)-octahydro-4-[(1,1-dimethylethyl)dimethylsilyloxy]-1-[(R)-2-hydroxy-1-methylethyl]-7a-methyl-1H-indene

Chemical Property:

Purity/Quality:

95%+ or 98%+ ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,3aR,4S,7aR)-octahydro-4-[(1,1-dimethylethyl)dimethylsilyloxy]-1-[(R)-2-hydroxy-1-methylethyl]-7a-methyl-1H-indene

There total 14 articles about (1R,3aR,4S,7aR)-octahydro-4-[(1,1-dimethylethyl)dimethylsilyloxy]-1-[(R)-2-hydroxy-1-methylethyl]-7a-methyl-1H-indene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

[1R-[1α(S*),3aβ,4α,7aα]]-α,7a-dimethyl-4-[[dimethyl-(1,1-dimethylethyl)silyl]oxy]-octahydro-1H-indene-1-acetaldehyde → (S)-2-((1R,3aR,4S,7aR)-4-(tert-butyldimethylsilyloxy)-7a-methyloctahydro-1H-inden-1-yl)propan-1-ol (100928-03-8,215509-33-4) + (1R,3aR,4S,7aR)-octahydro-4-[(1,1-dimethylethyl)dimethylsilyloxy]-1-[(R)-2-hydroxy-1-methylethyl]-7a-methyl-1H-indene (171011-48-6,215509-33-4)

Guidance literature:

[1R-[1α(S*),3aβ,4α,7aα]]-α,7a-dimethyl-4-[[dimethyl-(1,1-dimethylethyl)silyl]oxy]-octahydro-1H-indene-1-acetaldehyde; With sodium tetrahydroborate; ethanol; In tetrahydrofuran; at 20 ℃; for 0.5h;

With ammonium chloride; In tetrahydrofuran; water;

Reference yield: 55.0%

[1R-[1α(S*),3aβ,4α,7aα]]-α,7a-dimethyl-4-[[dimethyl-(1,1-dimethylethyl)silyl]oxy]-octahydro-1H-indene-1-acetaldehyde → (S)-2-[(1R,3aR,4S,7aR)-4-(tert-Butyl-dimethylsilanyloxy)-7a-methyl-octahydro-inden-1-yl]-propan-1-ol (215509-33-4) + (1R,3aR,4S,7aR)-octahydro-4-[(1,1-dimethylethyl)dimethylsilyloxy]-1-[(R)-2-hydroxy-1-methylethyl]-7a-methyl-1H-indene (171011-48-6,215509-33-4)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; ethanol; at 20 ℃; for 0.5h;

Reference yield: 55.0%

(S)-2-[(1R,3aR,4S,7aR)-octahydro-4-[(1,1-dimethylethyl)dimethylsilyloxy]-7a-methyl-1H-inden-1-yl]propanal (104651-47-0) + (20R)-de-A,B-8β-(tert-butyldimethylsilyl)oxy-20-formylpregnane (183506-74-3) + (1R,3aR,4S,7aR)-octahydro-4-[(1,1-dimethylethyl)dimethylsilyloxy]-1-[(R)-2-hydroxy-1-methylethyl]-7a-methyl-1H-indene (171011-48-6,215509-33-4)

Guidance literature:

(S)-2-[(1R,3aR,4S,7aR)-octahydro-4-[(1,1-dimethylethyl)dimethylsilyloxy]-7a-methyl-1H-inden-1-yl]propanal; (20R)-de-A,B-8β-(tert-butyldimethylsilyl)oxy-20-formylpregnane; With sodium tetrahydroborate; In tetrahydrofuran; ethanol; at 20 ℃; for 0.5h;

With hydrogenchloride; ammonia; In tetrahydrofuran; ethanol; water;

upstream raw materials:

(S)-2-[(1R,3aR,4S,7aR)-octahydro-4-[(1,1-dimethylethyl)dimethylsilyloxy]-7a-methyl-1H-inden-1-yl]propanal

(S)-2-((3R,3aR,7S,7aR)-octahydro-7-hydroxy-3a-methyl-1H-inden-3-yl)propyl 4-methylbenzenesulfonate

(8S,20S)-de-A,B-20-(hydroxymethyl)pregnan-8-ol

(S)-2-((1R,3aR,4S,7aR)-4-((tert-butyldimethylsilyl)oxy)-7a-methyloctahydro-1H-inden-1-yl)propyl 4-methylbenzenesulfonate

Downstream raw materials:

(R)-2-((1R,3aR,4S,7aR)-4-(tert-butyldimethylsilyloxy)-7a-methyloctahyrdo-1H-inden-1-yl)propyl 4-methylbenzenesulfonate

(R)-2-[(1R,3aR,4S,7aR)-octahydro-4-(1,1-dimethylethyl)dimethylsilyloxy-7a-methyl-1H-inden-1-yl]propyl 4-(9-tetrahydropyranyloxynonan-1-oxy)benzenesulfonate

20-epi-25-hydroxyvitamin D₃

20-epi-vitamin D₃