(2-nitro-4-octadecylcarbamoyl-benzyl)-carbamic acid tert-butyl ester

Base Information

• Chemical Name: (2-nitro-4-octadecylcarbamoyl-benzyl)-carbamic acid tert-butyl ester
• CAS No.: 891090-80-5
• Molecular Formula: C₃₁H₅₃N₃O₅
• Molecular Weight: 547.779
• Mol file: 891090-80-5.mol

Synonyms:(2-nitro-4-octadecylcarbamoyl-benzyl)-carbamic acid tert-butyl ester

Chemical Property of (2-nitro-4-octadecylcarbamoyl-benzyl)-carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2-nitro-4-octadecylcarbamoyl-benzyl)-carbamic acid tert-butyl ester

There total 6 articles about (2-nitro-4-octadecylcarbamoyl-benzyl)-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

4-(((tert-butoxycarbonyl)amino)methyl)-3-nitrobenzoic acid (56047-52-0) + 1-aminooctadecane (124-30-1) → (2-nitro-4-octadecylcarbamoyl-benzyl)-carbamic acid tert-butyl ester (891090-80-5)

Guidance literature:

With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In chloroform; at 20 ℃; for 10h;

DOI:10.1039/b503423j

Reference yield:

p-aminomethylbenzoic acid (56-91-7) → (2-nitro-4-octadecylcarbamoyl-benzyl)-carbamic acid tert-butyl ester (891090-80-5)

Guidance literature:

Multi-step reaction with 5 steps

1: 88 percent / 2 h / 25 °C

2: 92 percent / aq. nitric acid / 1.5 h / 0 °C

3: K₂CO₃; H₂O / methanol / 10 h / 25 °C

4: 0.67 g / dioxane; H₂O / 2.5 h

5: 81 percent / HOBT; Et₃N; HBTU / CHCl₃ / 10 h / 20 °C

With water; nitric acid; potassium carbonate; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In 1,4-dioxane; methanol; chloroform; water;

DOI:10.1039/b518359f

Reference yield:

4-(aminomethyl)-3-nitrobenzoic acid (2372-51-2) → (2-nitro-4-octadecylcarbamoyl-benzyl)-carbamic acid tert-butyl ester (891090-80-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 0.67 g / dioxane; H₂O / 2.5 h

2: 81 percent / HOBT; Et₃N; HBTU / CHCl₃ / 10 h / 20 °C

With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In 1,4-dioxane; chloroform; water;

DOI:10.1039/b518359f

upstream raw materials:

4-(((tert-butoxycarbonyl)amino)methyl)-3-nitrobenzoic acid

1-aminooctadecane

4-[[(2,2,2-trifluoroacetyl)amino]methyl]benzoic acid

3-nitro-4-{[(trifluoroacetyl)amino]methyl}benzoic acid

Downstream raw materials:

[5-t-butoxycarbonylamino-1-(2-nitro-4-octadecylcarbamoylbenzylcarbamoyl)pentyl]carbamic acid t-butyl ester

4-t-butoxycarbonylamino-4-(2-nitro-4-octadecylcarbamoylbenzylcarbamoyl)butyric acid t-butyl ester

3-t-butoxycarbonylamino-N-(2-nitro-4-octadecylcarbamoylbenzyl)succinamic acid t-butyl ester

N-stearyl-4-(aminomethyl)-3-nitrobenzamide