2-amino-2-(fluoromethyl)-4-(4-octylphenyl)butyl dihydrogenphosphate

Base Information

• Chemical Name: 2-amino-2-(fluoromethyl)-4-(4-octylphenyl)butyl dihydrogenphosphate
• CAS No.: 1352716-68-7
• Molecular Formula: C₁₉H₃₃FNO₄P
• Molecular Weight: 389.447
• Mol file: 1352716-68-7.mol

Synonyms:2-amino-2-(fluoromethyl)-4-(4-octylphenyl)butyl dihydrogenphosphate

Chemical Property of 2-amino-2-(fluoromethyl)-4-(4-octylphenyl)butyl dihydrogenphosphate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-amino-2-(fluoromethyl)-4-(4-octylphenyl)butyl dihydrogenphosphate

There total 10 articles about 2-amino-2-(fluoromethyl)-4-(4-octylphenyl)butyl dihydrogenphosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

2-amino-2-(fluoromethyl)-4-(4-octylphenyl)butan-1-ol → 2-amino-2-(fluoromethyl)-4-(4-octylphenyl)butyl dihydrogenphosphate (1352716-68-7)

Guidance literature:

2-amino-2-(fluoromethyl)-4-(4-octylphenyl)butan-1-ol; With trimethyl phosphite; trichlorophosphate; at 0 ℃; for 4h;

With water; sodium hydroxide; Product distribution / selectivity; Cooling with ice;

Reference yield:

1-Bromo-3-phenylpropane (637-59-2) → 2-amino-2-(fluoromethyl)-4-(4-octylphenyl)butyl dihydrogenphosphate (1352716-68-7)

Guidance literature:

Multi-step reaction with 10 steps

1.1: silver nitrate / diethyl ether / 22 h / 0 - 20 °C

2.1: aluminum (III) chloride / 1,2-dichloro-ethane / 12.33 h / 0 - 20 °C

2.2: Cooling with ice

3.1: trifluoroacetic acid; triethylsilane / 5 h / 20 °C

4.1: sodium hydroxide / 1,4-dioxane; ethanol; water / 16 h / 20 °C

5.1: thionyl chloride / dichloromethane / 5 h / 20 °C

6.1: sodium periodate / ruthenium trichloride / dichloromethane; acetonitrile; water / 2 h / 20 °C

7.1: tetramethylammonium fluoride / acetonitrile / 0.17 h / Reflux

8.1: hydrogenchloride / water / 1 h / Reflux

9.1: hydrogen / palladium 10% on activated carbon / ethanol / 18 h / 1900.13 Torr

10.1: trichlorophosphate; trimethyl phosphite / 4 h / 0 °C

10.2: Cooling with ice

With trimethyl phosphite; hydrogenchloride; triethylsilane; aluminum (III) chloride; sodium periodate; thionyl chloride; tetramethylammonium fluoride; hydrogen; silver nitrate; trifluoroacetic acid; sodium hydroxide; trichlorophosphate; ruthenium trichloride; palladium 10% on activated carbon; In 1,4-dioxane; diethyl ether; ethanol; dichloromethane; water; 1,2-dichloro-ethane; acetonitrile;

Reference yield:

C19H29NO5S → 2-amino-2-(fluoromethyl)-4-(4-octylphenyl)butyl dihydrogenphosphate (1352716-68-7)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium periodate / ruthenium trichloride / dichloromethane; acetonitrile; water / 2 h / 20 °C

2.1: tetramethylammonium fluoride / acetonitrile / 0.17 h / Reflux

3.1: hydrogenchloride / water / 1 h / Reflux

4.1: hydrogen / palladium 10% on activated carbon / ethanol / 18 h / 1900.13 Torr

5.1: trichlorophosphate; trimethyl phosphite / 4 h / 0 °C

5.2: Cooling with ice

With trimethyl phosphite; hydrogenchloride; sodium periodate; tetramethylammonium fluoride; hydrogen; trichlorophosphate; ruthenium trichloride; palladium 10% on activated carbon; In ethanol; dichloromethane; water; acetonitrile;

upstream raw materials:

1-Bromo-3-phenylpropane

(3-nitropropyl)benzene

2-nitro-2-[2-(4-octyl-phenyl)ethyl]propane-1,3-diol

C₁₉H₂₉NO₆S