1-(4-{[2'-(2-tert-Butyl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-amino}-2,6-dimethyl-pyrimidin-5-yl)-ethanone

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Chemical Name:1-(4-{[2'-(2-tert-Butyl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-amino}-2,6-dimethyl-pyrimidin-5-yl)-ethanone
CAS No.:1027898-62-9
Molecular Formula:C₂₆H₂₉N₇O
Molecular Weight:455.563
Hs Code.:

Synonyms:1-(4-{[2'-(2-tert-Butyl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-amino}-2,6-dimethyl-pyrimidin-5-yl)-ethanone

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Chemical Property of 1-(4-{[2'-(2-tert-Butyl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-amino}-2,6-dimethyl-pyrimidin-5-yl)-ethanone

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Technology Process of 1-(4-{[2'-(2-tert-Butyl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-amino}-2,6-dimethyl-pyrimidin-5-yl)-ethanone

There total 6 articles about 1-(4-{[2'-(2-tert-Butyl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-amino}-2,6-dimethyl-pyrimidin-5-yl)-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 2-[(2-t-butyl)-2H-tetrazol-5-yl]-phenylboronic acid

: 159237-74-8
methyl(4-(4-bromobenzylamino)-2,6-dimethylpyrimidin-5-yl)ketone

: 1027898-62-9
1-(4-{[2'-(2-tert-Butyl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-amino}-2,6-dimethyl-pyrimidin-5-yl)-ethanone

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; toluene; for 2.5h; Heating;
DOI:10.1021/jm970690q

Reference yield:

: 83410-16-6
4-chloro-5-iodo-2,6-dimethylpyrimidine

: 1027898-62-9
1-(4-{[2'-(2-tert-Butyl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-amino}-2,6-dimethyl-pyrimidin-5-yl)-ethanone

Guidance literature:: Multi-step reaction with 4 steps

1: 61 percent / LiCl, Pd(PPh₃)4 / dioxane / 25 h / Heating

2: 56 percent / NaHCO₃ / butan-1-ol / 70 h / Heating

3: 89 percent / 1N HCl / acetone / 2.5 h / Heating

4: 75 percent / Pd(PPh₃)4, aq. Na₂CO₃ / toluene; ethanol / 2.5 h / Heating

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; sodium carbonate; lithium chloride; In 1,4-dioxane; ethanol; acetone; toluene; butan-1-ol;
DOI:10.1021/jm970690q

Reference yield:

: 6622-92-0
4-hydroxy 2,6-dimethylpyrimidine

: 1027898-62-9
1-(4-{[2'-(2-tert-Butyl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-amino}-2,6-dimethyl-pyrimidin-5-yl)-ethanone

Guidance literature:: Multi-step reaction with 6 steps

1: 50 percent / iodine, 1N aq. NaOH / 2 h / Heating

2: 62 percent / POCl₃ / toluene / 1 h / Heating

3: 61 percent / LiCl, Pd(PPh₃)4 / dioxane / 25 h / Heating

4: 56 percent / NaHCO₃ / butan-1-ol / 70 h / Heating

5: 89 percent / 1N HCl / acetone / 2.5 h / Heating

6: 75 percent / Pd(PPh₃)4, aq. Na₂CO₃ / toluene; ethanol / 2.5 h / Heating

With hydrogenchloride; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; iodine; sodium hydrogencarbonate; sodium carbonate; lithium chloride; trichlorophosphate; In 1,4-dioxane; ethanol; acetone; toluene; butan-1-ol;
DOI:10.1021/jm970690q