6622-92-0

Basic information

• Product Name: 2,4-DIMETHYL-6-HYDROXYPYRIMIDINE
• Synonyms: 6-HYDROXY-2,4-DIMETHYLPYRIMIDINE;4-HYDROXY-2,6-DIMETHYLPYRIMIDINE;2,4-DIMETHYL-6-HYDROXYPYRIMIDINE;2,6-DIMETHYLPYRIMIDIN-4-OL;2,6-DIMETHYL-4-PYRIMIDINO;2,6-DIMETHYL-4-PYRIMIDINOL;2,6-DIMETHYL-4-HYDROXYPYRIMIDINE;2,4-Dimethyl-6-pyrimidinol
• CAS NO: 6622-92-0
• Molecular Formula: C₆H₈N₂O
• Molecular Weight: 124.14
• EINECS: 229-577-9
• Product Categories: PYRIMIDINE;APIs & Intermediate;alcohol
• Mol File: 6622-92-0.mol
• Article Data: 21

Chemical Properties

• Melting Point: 198.5-200 °C(lit.)
• Boiling Point: 230.92°C (rough estimate)
• Flash Point: 75.9 °C
• Appearance: White/Crystalline Needles
• Density: 1.1683 (rough estimate)
• Vapor Pressure: 0.301mmHg at 25°C
• Refractive Index: 1.5378 (estimate)
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 9.87±0.50(Predicted)
• BRN: 114324
• CAS DataBase Reference: 2,4-DIMETHYL-6-HYDROXYPYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-DIMETHYL-6-HYDROXYPYRIMIDINE(6622-92-0)
• EPA Substance Registry System: 2,4-DIMETHYL-6-HYDROXYPYRIMIDINE(6622-92-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 6622-92-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C6H8N2O/c1-4-3-6(9)8-5(2)7-4/h3H,1-2H3,(H,7,8,9)

Upstream product

• 674-82-8 4-methyleneoxetan-2-one 
• 124-42-5 acetamidine hydrochloride 
• 64-17-5 ethanol 
• 143-37-3 acetamidine 
• 68901-49-5 N-(3-methyl-isoxazol-5-yl)-acetamide 
• 141-97-9 ethyl acetoacetate 
• 28491-54-5 2-(4-methyl-6-oxo-1,6-dihydro-pyrimidin-2-yl)-acetamide 
• 4472-45-1 4-chloro-2,6-dimethylpyrimidine 
• 108-94-1 cyclohexanone 
• 77752-49-9 2,6-dimethyl-4-phenylsulfonylpyrimidine 
• 89088-70-0 1,2-Dihydro-2,6-dimethyl-4-pyrimidon-2-ylacetamide 
• 89088-71-1 1,5-Dimethyl-3,7-dioxo-2,6,9-triazabicyclo<3.3.1>nonane 
• 1446-19-1 diethyl N-acetyl L-glutamic ester 
• 64163-94-6 β-aminocrotonamide 

Downstream Products

• 354574-56-4 4-bromo-2,6-dimethylpyrimidine 
• 145910-14-1 methyl α-[2-(2',6'-dimethyl-4'-pyrimidinyl)-oxymethylphenyl]-β-methylacrylate 
• 40227-86-9 2,6-dimethyl-4-pyrimidinyl p-toluenesulfonate 
• 1262749-07-4 C₁₉H₂₅ClN₄O 
• 115879-67-9 2,6-dimethyl-4-(2-pyridylmethoxy)pyrimidine 
• 115879-66-8 2,6-dimethyl-3-(2-pyridylmethyl)pyrimidin-4(3H)-one 
• 75-58-1 tertamethylammonium iodide 
• 1445790-97-5 methyl 3-((3-carbamoyl-7-(2,4-dimethylpyrimidin-5-yl)-8-fluoroquinolin-4-yl)amino)-5-cyclopentylbenzate 
• 1445787-52-9 3-((3-carbamoyl-7-(2,4-dimethylpyrimidin-5-yl)-8-fluoroquinolin-4-yl)amino)-5-cyclopentylbenzoic acid 
• 1445790-91-9 methyl 3-((7-(2,4-dimethylpyrimidin-5-yl)-3-sulfamoylquinolin-4-yl)amino)-5-isopropoxybenzoate 

Relevant articles and documents

Ultrasound-Promoted Synthesis of 4-Pyrimidinols and Their Tosyl Derivatives

Ultrasound irradiation promoted the cyclocondensation of β-keto esters and amidines in good to excellent yields to form sixteen highly substituted 4-pyrimidinols. Tosylation of these compounds, in another ultrasound-promoted conversion, formed 4-pyrimidyl tosylates in high yields. The use of the developed protocol as an alternative route to 4-arylpyrimidines was illustrated with three examples of the Suzuki-Miyaura cross-coupling of the prepared tosylates with phenylboronic acid.

MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF

Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein

Interaction of acetonitrile with trifluoromethanesulfonic acid: Unexpected formation of a wide variety of structures

Interaction of acetonitrile with trifluoromethanesulfonic acid has been studied by multinuclear NMR and ESI-MS. It has been found that the interaction results in formation of a great variety of different cations and neutral compounds which is controlled by the ratio of CH3CN to TfOH. In the presence of an excess of the acid (molar ratio 1:8-14) diprotonated N-acetylacetamidine 1 is formed as the major product, which eventually transforms into protonated acetamidine 3 and acetic acid 4. At molar ratio of (1:1-2) diprotonated 2,4-dimethyl-6-methylidene-3H-1,3,5-triazine 12, tautomer of the diprotonated trimethyl-s-triazine 11, becomes the main product at an early stage of the reaction and diprotonated 1-(dimethyl-1,3,5-triazin-2-yl) prop-1-en-2-ol 15 at a later stage. In the case of a large excess of acetonitrile (4-20:1) trication 17 is formed as a result of the interaction between 11 and 12 along with some oligomers [(CH3CN) 3]n (n = 4-12). The Royal Society of Chemistry 2012.