ethyl (2R)-4-(5-fluoro-2-oxo-4-phenylpyridin-1(2H)-yl)-2-methyl-2-(methylsulfonyl)butanoic acid

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Chemical Name:ethyl (2R)-4-(5-fluoro-2-oxo-4-phenylpyridin-1(2H)-yl)-2-methyl-2-(methylsulfonyl)butanoic acid
CAS No.:1312479-50-7
Molecular Formula:C₁₇H₁₈FNO₅S
Molecular Weight:367.398
Hs Code.:

Synonyms:ethyl (2R)-4-(5-fluoro-2-oxo-4-phenylpyridin-1(2H)-yl)-2-methyl-2-(methylsulfonyl)butanoic acid

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Chemical Property of ethyl (2R)-4-(5-fluoro-2-oxo-4-phenylpyridin-1(2H)-yl)-2-methyl-2-(methylsulfonyl)butanoic acid

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Technology Process of ethyl (2R)-4-(5-fluoro-2-oxo-4-phenylpyridin-1(2H)-yl)-2-methyl-2-(methylsulfonyl)butanoic acid

There total 8 articles about ethyl (2R)-4-(5-fluoro-2-oxo-4-phenylpyridin-1(2H)-yl)-2-methyl-2-(methylsulfonyl)butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1312479-49-4
ethyl (2R)-4-(5-fluoro-2-oxo-4-phenylpyridin-1(2H)-yl)-2-methyl-2-(methylsulfonyl)butanoate

: 1312479-50-7
ethyl (2R)-4-(5-fluoro-2-oxo-4-phenylpyridin-1(2H)-yl)-2-methyl-2-(methylsulfonyl)butanoic acid

Guidance literature:: With potassium hydroxide; In 2-methyltetrahydrofuran; water; at 20 ℃;
DOI:10.1021/jm2014875

Reference yield: 73.6%

: 1312479-50-7
ethyl (2R)-4-(5-fluoro-2-oxo-4-phenylpyridin-1(2H)-yl)-2-methyl-2-(methylsulfonyl)butanoic acid

Guidance literature:

Reference yield:

: 1312478-47-9
ethyl (±)-4-bromo-2-methyl-2-(methylsulfonyl)butanoate

: 1312479-50-7
ethyl (2R)-4-(5-fluoro-2-oxo-4-phenylpyridin-1(2H)-yl)-2-methyl-2-(methylsulfonyl)butanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: ethanol / 0.02 h / Resolution of racemate

2: caesium carbonate / tetrahydrofuran; tert-butyl alcohol / 70 °C

3: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 2-methyltetrahydrofuran; water / 1 h / 60 °C

4: potassium hydroxide / 2-methyltetrahydrofuran; water / 20 °C

With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate; potassium hydroxide; In tetrahydrofuran; 2-methyltetrahydrofuran; ethanol; water; tert-butyl alcohol; 3: Suzuki-Miyaura coupling;
DOI:10.1021/jm2014875