4-deacetyl-7-(triethylsilyl)baccatin III 13-<(4S,5R)-3-(tert-butoxycarbonyl)-5-carboxyl-2,2-dimethyl-4-phenyl-1,3-oxazolidine>

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Chemical Name:4-deacetyl-7-(triethylsilyl)baccatin III 13-<(4S,5R)-3-(tert-butoxycarbonyl)-5-carboxyl-2,2-dimethyl-4-phenyl-1,3-oxazolidine>
CAS No.:160511-43-3
Molecular Formula:C₅₂H₇₁NO₁₄Si
Molecular Weight:962.22
Hs Code.:

Synonyms:4-deacetyl-7-(triethylsilyl)baccatin III 13-<(4S,5R)-3-(tert-butoxycarbonyl)-5-carboxyl-2,2-dimethyl-4-phenyl-1,3-oxazolidine>

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Chemical Property of 4-deacetyl-7-(triethylsilyl)baccatin III 13-<(4S,5R)-3-(tert-butoxycarbonyl)-5-carboxyl-2,2-dimethyl-4-phenyl-1,3-oxazolidine>

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Technology Process of 4-deacetyl-7-(triethylsilyl)baccatin III 13-<(4S,5R)-3-(tert-butoxycarbonyl)-5-carboxyl-2,2-dimethyl-4-phenyl-1,3-oxazolidine>

There total 5 articles about 4-deacetyl-7-(triethylsilyl)baccatin III 13-<(4S,5R)-3-(tert-butoxycarbonyl)-5-carboxyl-2,2-dimethyl-4-phenyl-1,3-oxazolidine> which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 143615-03-6,143527-70-2
(4S,5R)-3-(tert-butoxycarbonyl)-2,2-dimethyl-4-phenyloxazolidine-5-carboxylic acid

: 156605-41-3
4-deacetyl-7-(triethylsilyl)baccatin III

: 160511-43-3
4-deacetyl-7-(triethylsilyl)baccatin III 13-<(4S,5R)-3-(tert-butoxycarbonyl)-5-carboxyl-2,2-dimethyl-4-phenyl-1,3-oxazolidine>

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In toluene;
DOI:10.1016/0040-4039(94)85018-6

Reference yield: 65.0%

: 108-24-7
acetic anhydride

: 160768-74-1
4,10-bis(deacetyl)-7-triethylsily-13-((4S,5R)-N-tert-butoxycarbonyl-2,2-dimethyl-4-phenyl-5-oxazolidinyl)baccatin III

: 160511-43-3
4-deacetyl-7-(triethylsilyl)baccatin III 13-<(4S,5R)-3-(tert-butoxycarbonyl)-5-carboxyl-2,2-dimethyl-4-phenyl-1,3-oxazolidine>

Guidance literature:: With dicyclohexyl-carbodiimide; In tetrahydrofuran;
DOI:10.1016/0040-4039(94)85018-6

Reference yield:

: 115437-21-3
7-(triethylsilyl)baccatin III

: 160511-43-3
4-deacetyl-7-(triethylsilyl)baccatin III 13-<(4S,5R)-3-(tert-butoxycarbonyl)-5-carboxyl-2,2-dimethyl-4-phenyl-1,3-oxazolidine>

Guidance literature:: Multi-step reaction with 3 steps

1: 72 percent / potassium tert-butoxide / tetrahydrofuran

2: 90 percent / DCC, DMAP / toluene

3: 65 percent / DCC, 4-PP / tetrahydrofuran

With dmap; potassium tert-butylate; dicyclohexyl-carbodiimide; In tetrahydrofuran; toluene;
DOI:10.1016/0040-4039(94)85018-6