(E)-(4R,7R)-4-(tert-Butyl-dimethyl-silanyloxy)-7-((E)-(R)-5-hydroxy-hex-2-enoyloxy)-oct-2-enoic acid 2-benzenesulfonyl-ethyl ester

Base Information

Chemical Name:(E)-(4R,7R)-4-(tert-Butyl-dimethyl-silanyloxy)-7-((E)-(R)-5-hydroxy-hex-2-enoyloxy)-oct-2-enoic acid 2-benzenesulfonyl-ethyl ester
CAS No.:135100-94-6
Molecular Formula:C₂₈H₄₄O₈SSi
Molecular Weight:568.804
Hs Code.:

Synonyms:(E)-(4R,7R)-4-(tert-Butyl-dimethyl-silanyloxy)-7-((E)-(R)-5-hydroxy-hex-2-enoyloxy)-oct-2-enoic acid 2-benzenesulfonyl-ethyl ester

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Chemical Property of (E)-(4R,7R)-4-(tert-Butyl-dimethyl-silanyloxy)-7-((E)-(R)-5-hydroxy-hex-2-enoyloxy)-oct-2-enoic acid 2-benzenesulfonyl-ethyl ester

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Technology Process of (E)-(4R,7R)-4-(tert-Butyl-dimethyl-silanyloxy)-7-((E)-(R)-5-hydroxy-hex-2-enoyloxy)-oct-2-enoic acid 2-benzenesulfonyl-ethyl ester

There total 12 articles about (E)-(4R,7R)-4-(tert-Butyl-dimethyl-silanyloxy)-7-((E)-(R)-5-hydroxy-hex-2-enoyloxy)-oct-2-enoic acid 2-benzenesulfonyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: (E)-(4R,7R)-4-(tert-Butyl-dimethyl-silanyloxy)-7-[(E)-(R)-5-(2-ethoxy-ethoxy)-hex-2-enoyloxy]-oct-2-enoic acid 2-benzenesulfonyl-ethyl ester

: 135100-94-6
(E)-(4R,7R)-4-(tert-Butyl-dimethyl-silanyloxy)-7-((E)-(R)-5-hydroxy-hex-2-enoyloxy)-oct-2-enoic acid 2-benzenesulfonyl-ethyl ester

Guidance literature:: With magnesium bromide; In diethyl ether;
DOI:10.1016/0040-4039(91)80367-F

Reference yield:

: Acetic acid (R)-3-[(2R,3S)-3-(2-diazo-acetyl)-oxiranyl]-1-methyl-propyl ester

: 135100-94-6
(E)-(4R,7R)-4-(tert-Butyl-dimethyl-silanyloxy)-7-((E)-(R)-5-hydroxy-hex-2-enoyloxy)-oct-2-enoic acid 2-benzenesulfonyl-ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 2.) imidazole / 1.) hν, 2.) DMF

2: 85 percent / NaOMe, MeOH / 0 °C

3: 99 percent / PPTS / CH₂Cl₂

4: 98 percent / LiOH / tetrahydrofuran; H₂O

5: 68 percent / dicyclohexylcarbodiimide, DMAP / CH₂Cl₂

6: 99 percent / MgBr₂ / diethyl ether

7: 97 percent / DCC, DMAP / CH₂Cl₂

8: 78 percent / MgBr₂ / diethyl ether

With 1H-imidazole; methanol; dmap; lithium hydroxide; sodium methylate; pyridinium p-toluenesulfonate; dicyclohexyl-carbodiimide; magnesium bromide; In tetrahydrofuran; diethyl ether; dichloromethane; water;
DOI:10.1016/0040-4039(91)80367-F

Reference yield:

: 134828-82-3
Acetic acid (E)-(R)-6-hydroxy-1-methyl-hex-4-enyl ester

: 135100-94-6
(E)-(4R,7R)-4-(tert-Butyl-dimethyl-silanyloxy)-7-((E)-(R)-5-hydroxy-hex-2-enoyloxy)-oct-2-enoic acid 2-benzenesulfonyl-ethyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: 83 percent / D(-)DET, t-BuOOH, Ti(OiPr)4, mol sieves / CH₂Cl₂

3: 2.) imidazole / 1.) hν, 2.) DMF

4: 85 percent / NaOMe, MeOH / 0 °C

5: 99 percent / PPTS / CH₂Cl₂

6: 98 percent / LiOH / tetrahydrofuran; H₂O

7: 68 percent / dicyclohexylcarbodiimide, DMAP / CH₂Cl₂

8: 99 percent / MgBr₂ / diethyl ether

9: 97 percent / DCC, DMAP / CH₂Cl₂

10: 78 percent / MgBr₂ / diethyl ether

With 1H-imidazole; titanium(IV) isopropylate; methanol; tert.-butylhydroperoxide; dmap; lithium hydroxide; molecular sieve; diethyl (2S,3S)-tartrate; sodium methylate; pyridinium p-toluenesulfonate; dicyclohexyl-carbodiimide; magnesium bromide; In tetrahydrofuran; diethyl ether; dichloromethane; water;
DOI:10.1016/0040-4039(91)80367-F