(2R)-2-{[(1R)-1-(3,5-dimethylphenyl)-3-methyl-3-buten-1-yl]amino}-2-phenylethanol hydrochloride

Base Information

Chemical Name:(2R)-2-{[(1R)-1-(3,5-dimethylphenyl)-3-methyl-3-buten-1-yl]amino}-2-phenylethanol hydrochloride
CAS No.:499157-76-5
Molecular Formula:C₂₁H₂₇NO*ClH
Molecular Weight:345.912
Hs Code.:

Synonyms:(2R)-2-{[(1R)-1-(3,5-dimethylphenyl)-3-methyl-3-buten-1-yl]amino}-2-phenylethanol hydrochloride

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Chemical Property of (2R)-2-{[(1R)-1-(3,5-dimethylphenyl)-3-methyl-3-buten-1-yl]amino}-2-phenylethanol hydrochloride

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Technology Process of (2R)-2-{[(1R)-1-(3,5-dimethylphenyl)-3-methyl-3-buten-1-yl]amino}-2-phenylethanol hydrochloride

There total 4 articles about (2R)-2-{[(1R)-1-(3,5-dimethylphenyl)-3-methyl-3-buten-1-yl]amino}-2-phenylethanol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 5779-95-3
3,5-dimethylbenzaldehyde

: 56613-80-0
D-2-phenylglycinol

: 5674-01-1
2-methylallylmagnesium chloride

: 499157-76-5
(2R)-2-{[(1R)-1-(3,5-dimethylphenyl)-3-methyl-3-buten-1-yl]amino}-2-phenylethanol hydrochloride

: (2R)-2-{[(1S)-1-(3,5-dimethylphenyl)-3-methyl-3-buten-1-yl]amino}-2-phenylethanol hydrochloride

Guidance literature:: 3,5-dimethylbenzaldehyde; D-2-phenylglycinol; In toluene; for 15h; Reflux;

2-methylallylmagnesium chloride; In tetrahydrofuran; toluene; at 0 ℃; for 0.5h; Inert atmosphere;

With hydrogenchloride; In 1,4-dioxane; ethyl acetate; optical yield given as %de;
DOI:10.1016/j.bmc.2010.03.028

Reference yield:

: 499157-74-3
(2R)-3-aza-4-(3,5-dimethylphenyl)-2-phenyl-3-buten-1-ol

: 499157-76-5
(2R)-2-{[(1R)-1-(3,5-dimethylphenyl)-3-methyl-3-buten-1-yl]amino}-2-phenylethanol hydrochloride

Guidance literature:: 3-Chloro-2-methylpropene; With magnesium; In tetrahydrofuran; at 0 - 20 ℃; for 2.5h;

(2R)-3-aza-4-(3,5-dimethylphenyl)-2-phenyl-3-buten-1-ol; In tetrahydrofuran; toluene; at 0 ℃; for 3.5h;

Reference yield:

: (2R)-3-aza-2-phenyl-4-(3,5-dimethylphenyl)but-3-en-1-ol

: 563-47-3
3-Chloro-2-methylpropene

: 499157-76-5
(2R)-2-{[(1R)-1-(3,5-dimethylphenyl)-3-methyl-3-buten-1-yl]amino}-2-phenylethanol hydrochloride

Guidance literature:: 3-Chloro-2-methylpropene; With magnesium; In tetrahydrofuran; at 0 - 20 ℃; for 2.5h;

(2R)-3-aza-2-phenyl-4-(3,5-dimethylphenyl)but-3-en-1-ol; In tetrahydrofuran; toluene; for 3.5h;