butyl trans-4-(chlorocarbonyl)cyclohexanecarboxylate

Base Information

• Chemical Name: butyl trans-4-(chlorocarbonyl)cyclohexanecarboxylate
• CAS No.: 127873-17-0
• Molecular Formula: C₁₂H₁₉ClO₃
• Molecular Weight: 246.734
• Mol file: 127873-17-0.mol

Synonyms:butyl trans-4-(chlorocarbonyl)cyclohexanecarboxylate

Chemical Property of butyl trans-4-(chlorocarbonyl)cyclohexanecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of butyl trans-4-(chlorocarbonyl)cyclohexanecarboxylate

There total 2 articles about butyl trans-4-(chlorocarbonyl)cyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

trans-Cyclohexane-1,4-dicarboxylic acid monobutyl ester (127873-16-9) → butyl trans-4-(chlorocarbonyl)cyclohexanecarboxylate (127873-17-0)

Guidance literature:

With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 0 - 20 ℃; for 14h; Inert atmosphere;

Reference yield:

→ butyl trans-4-(chlorocarbonyl)cyclohexanecarboxylate (127873-17-0)

Guidance literature:

trans-Hexahydroterephthalsaeure-monobutylester, Thionylchlorid;

Reference yield:

butyl trans-4-(chlorocarbonyl)cyclohexanecarboxylate (127873-17-0) → trans-butyl 4-(1-(5-chloropyridin-2-yl)-1-hydroxyethyl)cyclohexane-carboxylate (1411772-43-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / toluene; tetrahydrofuran / 2 h / 15 - 20 °C

2.1: tert.-butyl lithium / dichloromethane; hexane / 1.5 h / -78 °C

2.2: 16 h / 23 °C

With tert.-butyl lithium; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; hexane; dichloromethane; toluene;

upstream raw materials:

trans-Cyclohexane-1,4-dicarboxylic acid monobutyl ester

Downstream raw materials:

trans-butyl 4-(1-(5-chloropyridin-2-yl)-1-hydroxyethyl)cyclohexane-carboxylate