trans-butyl 4-(1-(5-chloropyridin-2-yl)-1-hydroxyethyl)cyclohexane-carboxylate

Base Information

Chemical Name:trans-butyl 4-(1-(5-chloropyridin-2-yl)-1-hydroxyethyl)cyclohexane-carboxylate
CAS No.:1411772-43-4
Molecular Formula:C₁₈H₂₆ClNO₃
Molecular Weight:339.862
Hs Code.:

Synonyms:trans-butyl 4-(1-(5-chloropyridin-2-yl)-1-hydroxyethyl)cyclohexane-carboxylate

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Chemical Property of trans-butyl 4-(1-(5-chloropyridin-2-yl)-1-hydroxyethyl)cyclohexane-carboxylate

Chemical Property:

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Technology Process of trans-butyl 4-(1-(5-chloropyridin-2-yl)-1-hydroxyethyl)cyclohexane-carboxylate

There total 3 articles about trans-butyl 4-(1-(5-chloropyridin-2-yl)-1-hydroxyethyl)cyclohexane-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 40473-01-6
2-Bromo-5-chloro-pyridine

: 897053-86-0
butyl trans-4-acetylcyclohexanecarboxylate

: 1411772-43-4
trans-butyl 4-(1-(5-chloropyridin-2-yl)-1-hydroxyethyl)cyclohexane-carboxylate

Guidance literature:: 2-Bromo-5-chloro-pyridine; With tert.-butyl lithium; In hexane; dichloromethane; at -78 ℃; for 1.5h;

butyl trans-4-acetylcyclohexanecarboxylate; In dichloromethane; at 23 ℃; for 16h;

Reference yield:

: 127873-16-9
trans-Cyclohexane-1,4-dicarboxylic acid monobutyl ester

: 1411772-43-4
trans-butyl 4-(1-(5-chloropyridin-2-yl)-1-hydroxyethyl)cyclohexane-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 14 h / 0 - 20 °C / Inert atmosphere

2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / toluene; tetrahydrofuran / 2 h / 15 - 20 °C

3.1: tert.-butyl lithium / dichloromethane; hexane / 1.5 h / -78 °C

3.2: 16 h / 23 °C

With oxalyl dichloride; tert.-butyl lithium; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; N,N-dimethyl-formamide; In tetrahydrofuran; hexane; dichloromethane; toluene;

Reference yield:

: 127873-17-0
butyl trans-4-(chlorocarbonyl)cyclohexanecarboxylate

: 1411772-43-4
trans-butyl 4-(1-(5-chloropyridin-2-yl)-1-hydroxyethyl)cyclohexane-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / toluene; tetrahydrofuran / 2 h / 15 - 20 °C

2.1: tert.-butyl lithium / dichloromethane; hexane / 1.5 h / -78 °C

2.2: 16 h / 23 °C

With tert.-butyl lithium; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; hexane; dichloromethane; toluene;