methyl (E)-3-[1-[4-chloro-2-[(2-ethoxy-3-methoxyphenyl)hydroxymethyl]phenyl]-1H-pyrrol-2-yl]acrylate

Base Information

Chemical Name:methyl (E)-3-[1-[4-chloro-2-[(2-ethoxy-3-methoxyphenyl)hydroxymethyl]phenyl]-1H-pyrrol-2-yl]acrylate
CAS No.:937058-78-1
Molecular Formula:C₂₄H₂₄ClNO₅
Molecular Weight:441.911
Hs Code.:

Synonyms:methyl (E)-3-[1-[4-chloro-2-[(2-ethoxy-3-methoxyphenyl)hydroxymethyl]phenyl]-1H-pyrrol-2-yl]acrylate

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Chemical Property of methyl (E)-3-[1-[4-chloro-2-[(2-ethoxy-3-methoxyphenyl)hydroxymethyl]phenyl]-1H-pyrrol-2-yl]acrylate

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Technology Process of methyl (E)-3-[1-[4-chloro-2-[(2-ethoxy-3-methoxyphenyl)hydroxymethyl]phenyl]-1H-pyrrol-2-yl]acrylate

There total 6 articles about methyl (E)-3-[1-[4-chloro-2-[(2-ethoxy-3-methoxyphenyl)hydroxymethyl]phenyl]-1H-pyrrol-2-yl]acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 937058-76-9
methyl (E)-3-[1-[4-chloro-2-(2-ethoxy-3-methoxybenzoyl)phenyl]-1H-pyrrol-2-yl]acrylate

: 937058-78-1
methyl (E)-3-[1-[4-chloro-2-[(2-ethoxy-3-methoxyphenyl)hydroxymethyl]phenyl]-1H-pyrrol-2-yl]acrylate

Guidance literature:: With sodium tetrahydroborate; In methanol; at 0 - 20 ℃; for 1.5h;

Reference yield:

: 66799-97-1
2-ethoxy-3-methoxybenzaldehyde

: 937058-78-1
methyl (E)-3-[1-[4-chloro-2-[(2-ethoxy-3-methoxyphenyl)hydroxymethyl]phenyl]-1H-pyrrol-2-yl]acrylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / diethyl ether; hexane / 1.08 h / -78 - 20 °C

1.2: 1 h / -78 - 20 °C

2.1: manganese(IV) oxide / dichloromethane / 19.5 h / 20 °C / Heating / reflux

3.1: trichlorophosphate / 1,2-dichloro-ethane / 0.17 h / 0 - 20 °C

3.2: 3.5 h / 0 °C / Heating / reflux

3.3: 1 h / Heating / reflux

4.1: toluene / 5 h / Heating / reflux

5.1: sodium tetrahydroborate / methanol / 1.5 h / 0 - 20 °C

With manganese(IV) oxide; sodium tetrahydroborate; n-butyllithium; trichlorophosphate; In methanol; diethyl ether; hexane; dichloromethane; 1,2-dichloro-ethane; toluene;

Reference yield:

: 937059-69-3
1-(2-bromo-4-chloro-phenyl)-1H-pyrrole

: 937058-78-1
methyl (E)-3-[1-[4-chloro-2-[(2-ethoxy-3-methoxyphenyl)hydroxymethyl]phenyl]-1H-pyrrol-2-yl]acrylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / diethyl ether; hexane / 1.08 h / -78 - 20 °C

1.2: 1 h / -78 - 20 °C

2.1: manganese(IV) oxide / dichloromethane / 19.5 h / 20 °C / Heating / reflux

3.1: trichlorophosphate / 1,2-dichloro-ethane / 0.17 h / 0 - 20 °C

3.2: 3.5 h / 0 °C / Heating / reflux

3.3: 1 h / Heating / reflux

4.1: toluene / 5 h / Heating / reflux

5.1: sodium tetrahydroborate / methanol / 1.5 h / 0 - 20 °C

With manganese(IV) oxide; sodium tetrahydroborate; n-butyllithium; trichlorophosphate; In methanol; diethyl ether; hexane; dichloromethane; 1,2-dichloro-ethane; toluene;