[1-(2-benzyloxy-7,7-dimethyl-5-oxo-3,4,5,6,7,8-hexahydro-2H-chromen-4-yl)-ethyl]-carbamic acid benzyl ester

Base Information

Chemical Name:[1-(2-benzyloxy-7,7-dimethyl-5-oxo-3,4,5,6,7,8-hexahydro-2H-chromen-4-yl)-ethyl]-carbamic acid benzyl ester
CAS No.:1027934-36-6
Molecular Formula:C₂₈H₃₃NO₅
Molecular Weight:463.574
Hs Code.:

[1-(2-benzyloxy-7,7-dimethyl-5-oxo-3,4,5,6,7,8-hexahydro-2<i>H</i>-chromen-4-yl)-ethyl]-carbamic acid benzyl ester

Synonyms:[1-(2-benzyloxy-7,7-dimethyl-5-oxo-3,4,5,6,7,8-hexahydro-2H-chromen-4-yl)-ethyl]-carbamic acid benzyl ester

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Chemical Property of [1-(2-benzyloxy-7,7-dimethyl-5-oxo-3,4,5,6,7,8-hexahydro-2H-chromen-4-yl)-ethyl]-carbamic acid benzyl ester

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Technology Process of [1-(2-benzyloxy-7,7-dimethyl-5-oxo-3,4,5,6,7,8-hexahydro-2H-chromen-4-yl)-ethyl]-carbamic acid benzyl ester

There total 3 articles about [1-(2-benzyloxy-7,7-dimethyl-5-oxo-3,4,5,6,7,8-hexahydro-2H-chromen-4-yl)-ethyl]-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 935-04-6
benzyl vinyl ether

: 105499-10-3
(1(S)-methyl-2-oxo-ethyl)-carbamic acid benzyl ester

: 126-81-8
dimedone

: 1027934-36-6
[1-(2-benzyloxy-7,7-dimethyl-5-oxo-3,4,5,6,7,8-hexahydro-2H-chromen-4-yl)-ethyl]-carbamic acid benzyl ester

Guidance literature:: With ethylenediamine diacetic acid; trimethyl orthoformate; In toluene; at 50 - 60 ℃; for 15h; ultrasound;
DOI:10.1002/1521-3773(20010302)40:5<903::AID-ANIE903>3.0.CO;2-7

Reference yield:

: 4132-86-9,26607-51-2,1142-20-7
N-benzyloxycarbonylalanine

: 1027934-36-6
[1-(2-benzyloxy-7,7-dimethyl-5-oxo-3,4,5,6,7,8-hexahydro-2H-chromen-4-yl)-ethyl]-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: ROH; camphor sulfonic acid / 15 h / Heating

1.2: DIBAL-H / hexane; CH₂Cl₂ / 2 h / -78 °C

2.1: trimethyl orthoformate; ethylenediammonium diacetate / toluene / 15 h / 50 - 60 °C / ultrasound

With camphor-10-sulfonic acid; ethylenediamine diacetic acid; trimethyl orthoformate; In toluene; 2.1: Knoevenagel/hetero-Diels-Alder reaction;
DOI:10.1002/1521-3773(20010302)40:5<903::AID-ANIE903>3.0.CO;2-7

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 1027934-36-6
[1-(2-benzyloxy-7,7-dimethyl-5-oxo-3,4,5,6,7,8-hexahydro-2H-chromen-4-yl)-ethyl]-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: aq. NaOH / 15 h / 20 °C

2.1: ROH; camphor sulfonic acid / 15 h / Heating

2.2: DIBAL-H / hexane; CH₂Cl₂ / 2 h / -78 °C

3.1: trimethyl orthoformate; ethylenediammonium diacetate / toluene / 15 h / 50 - 60 °C / ultrasound

With sodium hydroxide; camphor-10-sulfonic acid; ethylenediamine diacetic acid; trimethyl orthoformate; In toluene; 3.1: Knoevenagel/hetero-Diels-Alder reaction;
DOI:10.1002/1521-3773(20010302)40:5<903::AID-ANIE903>3.0.CO;2-7