methyl (2-chlorophenyl)[4-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1H-1,2,3-triazol-1-yl]acetate

Base Information

Chemical Name:methyl (2-chlorophenyl)[4-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1H-1,2,3-triazol-1-yl]acetate
CAS No.:1332502-24-5
Molecular Formula:C₂₃H₁₉Cl₂F₃N₆O₄
Molecular Weight:571.343
Hs Code.:

methyl (2-chlorophenyl)[4-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1H-1,2,3-triazol-1-yl]acetate

Synonyms:methyl (2-chlorophenyl)[4-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1H-1,2,3-triazol-1-yl]acetate

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Chemical Property of methyl (2-chlorophenyl)[4-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1H-1,2,3-triazol-1-yl]acetate

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Technology Process of methyl (2-chlorophenyl)[4-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1H-1,2,3-triazol-1-yl]acetate

There total 6 articles about methyl (2-chlorophenyl)[4-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1H-1,2,3-triazol-1-yl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1332502-74-5
5-(4-chlorophenyl)-2-(prop-2-yn-1-yl)-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazol-3-one

: 85259-19-4,622835-93-2,66504-71-0
methyl 2-bromo-2-(2-chlorophenyl)acetate

: 1332502-24-5
methyl (2-chlorophenyl)[4-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1H-1,2,3-triazol-1-yl]acetate

Guidance literature:: methyl 2-bromo-2-(2-chlorophenyl)acetate; With sodium azide; In acetonitrile; at 20 ℃; for 1h;

5-(4-chlorophenyl)-2-(prop-2-yn-1-yl)-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazol-3-one; With copper(II) acetate monohydrate; In acetonitrile; at 50 ℃; for 48h;

Reference yield:

: 536-40-3
4-chlorobenzoic acid hydrazide

: 1332502-24-5
methyl (2-chlorophenyl)[4-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1H-1,2,3-triazol-1-yl]acetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrahydrofuran / 50 °C

2.1: sodium hydroxide; water / Reflux

2.2: 20 °C / pH 1

3.1: pyridine / 0.5 h / 35 °C / Inert atmosphere

3.2: 70 °C

4.1: formic acid; triethylamine; [N-[(1R,2R)-2-(amino-κN)-1,2-diphenylethyl]-4-methylbenzenesulfonamidato-κN]chloro[(1,2, 3,4,5,6-η)-1-methyl-4-(1-methylethyl)benzene]-ruthenium / N,N-dimethyl acetamide / 48 h / 20 °C / Inert atmosphere

5.1: caesium carbonate / acetonitrile / 1 h / Reflux

6.1: sodium azide / acetonitrile / 1 h / 20 °C

6.2: 48 h / 50 °C

With pyridine; formic acid; sodium azide; [N-[(1R,2R)-2-(amino-κN)-1,2-diphenylethyl]-4-methylbenzenesulfonamidato-κN]chloro[(1,2, 3,4,5,6-η)-1-methyl-4-(1-methylethyl)benzene]-ruthenium; water; caesium carbonate; triethylamine; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl acetamide; acetonitrile;

Reference yield:

: 1228650-21-2
ethyl N-({2-[(4-chlorophenyl)carbonyl]hydrazinyl}carbonyl)glycinate

: 1332502-24-5
methyl (2-chlorophenyl)[4-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1H-1,2,3-triazol-1-yl]acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide; water / Reflux

1.2: 20 °C / pH 1

2.1: pyridine / 0.5 h / 35 °C / Inert atmosphere

2.2: 70 °C

3.1: formic acid; triethylamine; [N-[(1R,2R)-2-(amino-κN)-1,2-diphenylethyl]-4-methylbenzenesulfonamidato-κN]chloro[(1,2, 3,4,5,6-η)-1-methyl-4-(1-methylethyl)benzene]-ruthenium / N,N-dimethyl acetamide / 48 h / 20 °C / Inert atmosphere

4.1: caesium carbonate / acetonitrile / 1 h / Reflux

5.1: sodium azide / acetonitrile / 1 h / 20 °C

5.2: 48 h / 50 °C

With pyridine; formic acid; sodium azide; [N-[(1R,2R)-2-(amino-κN)-1,2-diphenylethyl]-4-methylbenzenesulfonamidato-κN]chloro[(1,2, 3,4,5,6-η)-1-methyl-4-(1-methylethyl)benzene]-ruthenium; water; caesium carbonate; triethylamine; sodium hydroxide; In N,N-dimethyl acetamide; acetonitrile;