rac-3-amino-5-[3-(5-methoxy-pyridin-3-yl)-phenyl]-1,5-dimethyl-5,6-dihydro-1H-pyrazin-2-one

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Chemical Name:rac-3-amino-5-[3-(5-methoxy-pyridin-3-yl)-phenyl]-1,5-dimethyl-5,6-dihydro-1H-pyrazin-2-one
CAS No.:1353759-87-1
Molecular Formula:C₁₈H₂₀N₄O₂
Molecular Weight:324.382
Hs Code.:

Synonyms:rac-3-amino-5-[3-(5-methoxy-pyridin-3-yl)-phenyl]-1,5-dimethyl-5,6-dihydro-1H-pyrazin-2-one

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Chemical Property of rac-3-amino-5-[3-(5-methoxy-pyridin-3-yl)-phenyl]-1,5-dimethyl-5,6-dihydro-1H-pyrazin-2-one

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Technology Process of rac-3-amino-5-[3-(5-methoxy-pyridin-3-yl)-phenyl]-1,5-dimethyl-5,6-dihydro-1H-pyrazin-2-one

There total 11 articles about rac-3-amino-5-[3-(5-methoxy-pyridin-3-yl)-phenyl]-1,5-dimethyl-5,6-dihydro-1H-pyrazin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 850991-69-4
5-methoxy-3-pyridinylboronic acid

: 1353759-77-9
rac-3-amino-5-(3-bromo-phenyl)-1,5-dimethyl-5,6-dihydro-1H-pyrazin-2-one

: 1353759-87-1
rac-3-amino-5-[3-(5-methoxy-pyridin-3-yl)-phenyl]-1,5-dimethyl-5,6-dihydro-1H-pyrazin-2-one

Guidance literature:: With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; ethanol; at 150 ℃; for 0.5h; Inert atmosphere; Micriwave irradiatoin;

Reference yield:

: 2142-63-4
1-(3-Bromophenyl)ethanone

: 1353759-87-1
rac-3-amino-5-[3-(5-methoxy-pyridin-3-yl)-phenyl]-1,5-dimethyl-5,6-dihydro-1H-pyrazin-2-one

Guidance literature:: Multi-step reaction with 11 steps

1.1: ammonia; ammonium chloride / methanol / 96 h / 20 °C

2.1: hydrogenchloride / 96 h / Reflux

2.2: 20 °C / pH 8

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / -15 - 0 °C

4.1: sodium hydrogencarbonate / water; tetrahydrofuran / 15 h / 0 - 20 °C

4.2: pH 1 - 2 / Cooling with ice

5.1: Dess-Martin periodane / dichloromethane / 1 h / 0 - 20 °C

6.1: acetic acid / dichloromethane; tetrahydrofuran / 1 h / 20 °C

6.2: 5 h / 20 °C

7.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 0 °C / Cooling with ice

8.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

9.1: dichloromethane / 72 h / 20 °C

10.1: ammonium chloride / ethanol / 18 h / 75 °C

11.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; ethanol / 0.5 h / 150 °C / Inert atmosphere; Micriwave irradiatoin

With hydrogenchloride; lithium aluminium tetrahydride; ammonia; sodium hydrogencarbonate; potassium carbonate; ammonium chloride; Dess-Martin periodane; acetic acid; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water;

Reference yield:

: 953741-63-4
rac-2-amino-2-(3-bromo-phenyl)-propionitrile

: 1353759-87-1
rac-3-amino-5-[3-(5-methoxy-pyridin-3-yl)-phenyl]-1,5-dimethyl-5,6-dihydro-1H-pyrazin-2-one

Guidance literature:: Multi-step reaction with 10 steps

1.1: hydrogenchloride / 96 h / Reflux

1.2: 20 °C / pH 8

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / -15 - 0 °C

3.1: sodium hydrogencarbonate / water; tetrahydrofuran / 15 h / 0 - 20 °C

3.2: pH 1 - 2 / Cooling with ice

4.1: Dess-Martin periodane / dichloromethane / 1 h / 0 - 20 °C

5.1: acetic acid / dichloromethane; tetrahydrofuran / 1 h / 20 °C

5.2: 5 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 0 °C / Cooling with ice

7.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

8.1: dichloromethane / 72 h / 20 °C

9.1: ammonium chloride / ethanol / 18 h / 75 °C

10.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; ethanol / 0.5 h / 150 °C / Inert atmosphere; Micriwave irradiatoin

With hydrogenchloride; lithium aluminium tetrahydride; sodium hydrogencarbonate; potassium carbonate; ammonium chloride; Dess-Martin periodane; acetic acid; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water;