rac-3-amino-5-(3-bromo-phenyl)-1,5-dimethyl-5,6-dihydro-1H-pyrazin-2-one

Base Information

Chemical Name:rac-3-amino-5-(3-bromo-phenyl)-1,5-dimethyl-5,6-dihydro-1H-pyrazin-2-one
CAS No.:1353759-77-9
Molecular Formula:C₁₂H₁₄BrN₃O
Molecular Weight:296.167
Hs Code.:

Synonyms:rac-3-amino-5-(3-bromo-phenyl)-1,5-dimethyl-5,6-dihydro-1H-pyrazin-2-one

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Chemical Property of rac-3-amino-5-(3-bromo-phenyl)-1,5-dimethyl-5,6-dihydro-1H-pyrazin-2-one

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Technology Process of rac-3-amino-5-(3-bromo-phenyl)-1,5-dimethyl-5,6-dihydro-1H-pyrazin-2-one

There total 10 articles about rac-3-amino-5-(3-bromo-phenyl)-1,5-dimethyl-5,6-dihydro-1H-pyrazin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1353759-76-8
rac-5-(3-bromo-phenyl)-3-methoxy-1,5-dimethyl-5,6-dihydro-1H-pyrazin-2-one

: 1353759-77-9
rac-3-amino-5-(3-bromo-phenyl)-1,5-dimethyl-5,6-dihydro-1H-pyrazin-2-one

Guidance literature:: With ammonium chloride; In ethanol; at 75 ℃; for 18h;

Reference yield:

: 953741-63-4
rac-2-amino-2-(3-bromo-phenyl)-propionitrile

: 1353759-77-9
rac-3-amino-5-(3-bromo-phenyl)-1,5-dimethyl-5,6-dihydro-1H-pyrazin-2-one

Guidance literature:: Multi-step reaction with 9 steps

1.1: hydrogenchloride / 96 h / Reflux

1.2: 20 °C / pH 8

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / -15 - 0 °C

3.1: sodium hydrogencarbonate / water; tetrahydrofuran / 15 h / 0 - 20 °C

3.2: pH 1 - 2 / Cooling with ice

4.1: Dess-Martin periodane / dichloromethane / 1 h / 0 - 20 °C

5.1: acetic acid / dichloromethane; tetrahydrofuran / 1 h / 20 °C

5.2: 5 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 0 °C / Cooling with ice

7.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

8.1: dichloromethane / 72 h / 20 °C

9.1: ammonium chloride / ethanol / 18 h / 75 °C

With hydrogenchloride; lithium aluminium tetrahydride; sodium hydrogencarbonate; ammonium chloride; Dess-Martin periodane; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water;

Reference yield:

: 2142-63-4
1-(3-Bromophenyl)ethanone

: 1353759-77-9
rac-3-amino-5-(3-bromo-phenyl)-1,5-dimethyl-5,6-dihydro-1H-pyrazin-2-one

Guidance literature:: Multi-step reaction with 10 steps

1.1: ammonia; ammonium chloride / methanol / 96 h / 20 °C

2.1: hydrogenchloride / 96 h / Reflux

2.2: 20 °C / pH 8

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / -15 - 0 °C

4.1: sodium hydrogencarbonate / water; tetrahydrofuran / 15 h / 0 - 20 °C

4.2: pH 1 - 2 / Cooling with ice

5.1: Dess-Martin periodane / dichloromethane / 1 h / 0 - 20 °C

6.1: acetic acid / dichloromethane; tetrahydrofuran / 1 h / 20 °C

6.2: 5 h / 20 °C

7.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 0 °C / Cooling with ice

8.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

9.1: dichloromethane / 72 h / 20 °C

10.1: ammonium chloride / ethanol / 18 h / 75 °C

With hydrogenchloride; lithium aluminium tetrahydride; ammonia; sodium hydrogencarbonate; ammonium chloride; Dess-Martin periodane; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water;